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Raspberry Extract and Its Application

A technology of extract and raspberry, applied in the field of development and utilization of traditional Chinese medicine

Inactive Publication Date: 2016-08-17
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, modern medicine has no therapy that can terminate or reverse the pathological changes of senile dementia and play a fundamental therapeutic role.

Method used

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  • Raspberry Extract and Its Application
  • Raspberry Extract and Its Application
  • Raspberry Extract and Its Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Raspberry extract preparation

[0026] 1. Take the raspberry medicinal material and pulverize it, percolate with 75% ethanol until it is basically colorless, extract with chloroform and ethyl acetate respectively, and after recovering the solvent, obtain the extract of the chloroform part and the extract of the ethyl acetate part respectively;

[0027] 2. Dissolve the extract from the chloroform part with methanol, and put it on the polyamide column that has been wet packed with water. After elution with water, collect the water eluate, that is, the water eluate from the chloroform part;

[0028] After the polyamide column is eluted with water, it is eluted with ethanol, and the eluate is collected to obtain the ethanol eluate at the chloroform part;

[0029] The polyamide column is then eluted with ammonia water and methanol solution. After the eluate is neutralized with 4mol / L hydrochloric acid to neutral pH, it is loaded on D101 macroporous resin and elu...

Embodiment 2

[0037] Example 2 Effect of Raspberry Extract on Morphology of Hippocampal CA1 Area and Hyperphosphorylation of Tau Protein in Senile Dementia Rats with Kidney Yang Deficiency

[0038] Rabbit anti-Pser404-tau kit, product of Abgent; rabbit SP detection kit, Beijing Zhongshan Jinqiao Biotechnology Co., Ltd., batch number 11137A10; DAB chromogenic kit, Beijing Zhongshan Jinqiao Biotechnology Co., Ltd., batch number 911882A.

[0039] 1 Experimental method

[0040] 1.1 Modeling and administration

[0041] 120 SD rats, male, SPF grade, weighing 180-220 g, were provided by Hunan Slack Jingda Experimental Animal Co., Ltd., license number SCXK (Xiang) 2009-0004. After the experimental animals were adapted for 1 week, the animals were screened by the Morris water maze test, and 10 rats were eliminated (outliers, rats that could not always find the platform during the escape latency period) were randomly divided into 11 groups: blank group, model group, and brain group. Rehabilitation ...

Embodiment 3

[0069] Embodiment 3 Separation of the monomer components of the active part of raspberry

[0070] 1 Instruments and reagents

[0071] INOVA-500 nuclear magnetic resonance instrument (internal standard TMS), VGZAB-HS mass spectrometer, X4 micro melting point tester (B Beijing Tektronix Instrument Co., Ltd.), IR infrared, DU-650 ultraviolet-visible spectrometer (Beckman Corporation, USA) ), silica gel (Qingdao Haiyang Chemical Material Factory), polyamide (Zhejiang Taizhou Luqiao Sijia Biochemical Plastic Factory), SephadexLH-20 gel (Pharmacia Company), and other reagents were of analytical grade. The medicinal material of raspberry was purchased from camphor tree, and it was identified as the fruit of Rubus chingii Hu, a plant of the genus Rubus.

[0072] 2 Extraction and separation

[0073] After the raspberry medicinal material is crushed, percolate with 80% ethanol until the medicinal liquid is basically colorless, and recover the ethanol to obtain an extract. The extract...

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Abstract

The invention belongs to the field of development and utilization of traditional Chinese medicines and in particular relates to development and utilization of raspberry. The extract comprises any one of a washing part, an acetone elution part, a chloroform part and an ethyl acetate part and has the effects of preventing and treating Alzheimer disease. The raw materials come from green plants and the extract has wide development space and application prospects.

Description

technical field [0001] The invention belongs to the field of development and utilization of traditional Chinese medicines, and specifically designs the development and utilization of raspberries. Background technique [0002] Entering the 21st century, an aging society is approaching quietly. my country became an aging country at the end of 1999, and the elderly population in our country is growing at a rate of 3%. Among the elderly, the ranking order of diseases is heart disease, tumor, and cerebrovascular disease, and the fourth place is senile dementia. It is estimated that 10% of people over the age of 65 have mild to moderate dementia. 4-5% suffer from severe dementia, and this proportion exceeds 15% of the elderly over the age of 85. Some experts predict that senile dementia will be the number one killer of human beings in the 21st century. Currently, the number of senile dementia patients in the world is estimated to be 20-25 million. There are more than 4 million ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61P25/28
CPCA61K31/56A61K36/73A61K2236/333A61K2236/55
Inventor 谢一辉黄丽萍樊浩张雨恬龚嘉华练波
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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