A dendritic polymer drug delivery system with high tumor recognition and environment-responsive drug release capabilities and its construction method

Abstract

The invention discloses a dendrimer drug delivery system with high tumor recognition ability and environmental response drug release ability. The dendrimer drug delivery system comprises a dendrimer (Dendrimers), an antitumor drug (Drug), hydrophilic block polyethylene glycol (PEG) of undecorated ligand, and a targeting ligand chain with specific tumor recognition ability, wherein the dendrimer is the dendrimer with amino; the hydrophilic block PEG of the undecorated ligand and the targeting ligand chain are connected to the surface by taking the dendrimer as a center; the targeting ligand chain is a polyethylene glycol-targeting ligand intercalated compound PEG-X; and Drug is linked to the surface of the dendrimer through an acid sensitive chemical bond-hydrazone bond. By adopting the dendrimer drug delivery system, a plurality of functions of combining active targeting with passive targeting of the drug, response drug release inside a tumor microenvironment and an organelle and the like can be achieved, improvement of the targeting efficiency and accumulation of the drug in the tumor part are facilitated, and the pharmaceutical effect is enhanced. Thus, the dendrimer drug delivery system is a multifunctional tumor-targeted drug delivery system with potential.

Description

technical field [0001] The invention relates to a dendritic polymer drug delivery system with high tumor recognition and environmental response drug release capabilities and a construction method thereof. Background technique [0002] Cancer is a leading cause of death worldwide. According to the statistics of the World Health Organization (WHO), 10 million people in the world suffer from cancer every year, and about 6 million people die from cancer, accounting for 12% of the global death toll. There are 1.8 million new cancer patients and 1.4 million deaths in my country every year. On average, 1.3 people die of cancer every 3 minutes, and the incidence of cancer is rising sharply. Therefore, the treatment of cancer is of great significance. Tumor treatment methods include surgical treatment, radiotherapy and chemotherapy, biological immunity, etc. Chemotherapy is one of the main methods to treat tumors. However, chemotherapy treatment of tumors kills both normal cells and...

AI Technical Summary

Problems solved by technology

Tumor treatment methods include surgical treatment, radiotherapy and chemotherapy, biological immunity, etc. Chemotherapy is one of the main methods to treat tumors. However, chemotherapy treatment of tumors kills both normal cells and immune cells while killing tumor cells, which lacks selectivity.

In addition, the physical and chemical properties of the drug itself, such as molecular size, solubility, permeability, stability, and plasma protein binding, also greatly affect the efficacy of the drug

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