Chinese medicinal preparation for preventing lower extremity deep vein thrombosis after hip replacement

A technology for hip replacement and deep vein thrombosis, which is applied in the field of traditional Chinese medicine, can solve problems such as many contraindications, poor patient compliance, and large side effects, and achieve high safety performance and obvious effects

Inactive Publication Date: 2014-03-26
丁飞
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditionally, low-molecular-weight heparin is used to prevent deep vein thrombosis of lower extremities after hip replacement. It is made by degrading heparin with enzymes or chemical methods. It has a good antithrombotic effect and has a strong preventive effect on deep vein thrombosis of lower extremities. , easy to use, but it is easy to cause postoperative bleeding tendency. Although low molecular weight heparin has a certain effect in preventing deep vein thrombosis of lower extremities, it has many contraindications, large side effects, and poor patient compliance, especially for epidural surgery. Greater risk of epidural hematoma during perineural procedures such as anesthesia

Method used

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preparation example Construction

[0052] The present invention also provides a preparation method of the above-mentioned Chinese medicine preparation, when the dosage form of the Chinese medicine preparation is an oral liquid, specifically:

[0053] The first step is to crush the angelica, jujube, Selaginella, saffron, notoginseng, rhubarb, Qianjinba, Qianzhenwanxiancao, Guangxiangteng and Wangbuliuxing respectively, and mix them according to weight. The powder is dissolved in ethanol with an alcohol concentration of 70% to 80%, soaked for 24 hours to 36 hours, and slowly percolated at a rate of 2 to 4ml per minute by the percolation method, and the percolation liquid is collected. The mass of the added ethanol It is 5 to 8 times the mass of the mixed powder, concentrated under reduced pressure to 1 / 10 of the original volume, centrifuged to obtain the centrifuged supernatant, and the supernatant is absorbed by a macroporous resin column. First, use the mass of the mixture obtained in the first step 2-4 times o...

Embodiment 1

[0061] The preparation of embodiment 1 oral liquid 1

[0062] Crush 55g Angelica, 40g Jujube, 20g Selaginella, 25g Saffron, 40g Panax notoginseng, 25g Rhizoma Rhizoma, 30g Qianjinba, 20g Thousand Needles, 40g Guangxiangteng and 25g Wang Buliuxing, and mix them. Dissolve the mixed powder in 2 kg of ethanol with an alcohol concentration of 70%, soak for 24 hours, use the percolation method to slowly percolate at a speed of 4ml per minute, collect the percolation liquid, and concentrate it under reduced pressure to 1 / 1 of the original volume. 10. Centrifuge to obtain the supernatant. The supernatant is absorbed by a macroporous resin column, first eluted with 1 kg of water and discarded, and then eluted with gradient ethanol. Elution with 2.2kg alcohol concentration 80% ethanol, merge gradient ethanol eluent, reclaim ethanol under reduced pressure, obtain clear ointment, the relative density of described clear ointment is 1.18 (65 ℃), with Poria cocos 30g, Clematis 20g , Bupleur...

Embodiment 2

[0063] The preparation of embodiment 2 oral liquid 2

[0064] Crush 60g Angelica sinensis, 45g jujube, 25g Selaginella selaginella, 30g saffron, 45g Panax notoginseng, 30g Rhizoma rhubarb, 35g Qianjinba, 25g Thousand needles, 45g Guangxiangteng and 30g Wangbuliuxing respectively, mix them, Dissolve the mixed powder in 2.5kg of ethanol with an alcohol concentration of 70%, soak for 24 hours, use the percolation method to percolate slowly at a speed of 4ml per minute, collect the percolation liquid, and concentrate it under reduced pressure to 1% of the original volume. / 10, centrifuged to obtain the supernatant, the supernatant was absorbed by a macroporous resin column, first eluted with 1.5kg of water and discarded, then eluted with gradient ethanol, and eluted with 1.8kg of alcohol concentration 50% ethanol for the first time , then elute with 2.5kg alcohol concentration 80% ethanol, merge gradient ethanol eluent, reclaim ethanol under reduced pressure, obtain clear ointment...

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Abstract

The invention provides a Chinese medicinal preparation for preventing lower extremity deep vein thrombosis after hip replacement. The Chinese medicinal preparation comprises the following crude medicaments: Chinese angelica, jujubes, selaginella, saffron, Indian buead, pseudo-ginseng, clematis root, Chinese thorowax root, cassia twig, yam, heterophylly falsestarwort root, companumoea root, galanga resurrectionlily rhizome, franzenbach rhubarb root and rhizome, moghania philippinensis, stellaria yunnanensis, root-bark of manybract fissistigma, cowherb seeds and dogwood. The Chinese medicinal preparation has the effects of promoting blood circulation to remove blood stasis and relieving swelling and pain, and has remarkable prevention effects and high safety, thereby being an orthopedic post-operative medicament with high clinical popularization and application value.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for preventing deep vein thrombosis of lower limbs after hip joint replacement. Background technique [0002] With the continuous maturity of hip arthroplasty, it has increasingly become the primary means of clinical treatment of femoral neck fractures, femoral head necrosis, osteoarthritis and other femoral diseases, and has gradually been accepted and promoted by patients and medical workers. However, the formation of deep venous thrombosis in the lower extremities seriously affects the recovery of patients after operation, and even endangers the lives of patients. At present, reports of lower extremity deep vein thrombosis after hip replacement have attracted more and more attention. [0003] The mechanism of thrombus formation mainly includes the following aspects: surgery itself is a kind of trauma, which cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P7/02
Inventor 丁飞王静牟雪梅张治成
Owner 丁飞
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