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Chinese medicinal composition for preventing lower extremity deep vein thrombosis after hip replacement

A technology for hip replacement and deep vein thrombosis, applied in the field of traditional Chinese medicine, can solve the problems of many contraindications, poor patient compliance, and large side effects, and achieve the effect of high safety performance and obvious effect.

Inactive Publication Date: 2014-03-26
丁飞
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] Traditionally, low-molecular-weight heparin is used to prevent deep vein thrombosis of lower extremities after hip replacement. It is made by degrading heparin with enzymes or chemical methods. It has a good antithrombotic effect and has a strong preventive effect on deep vein thrombosis of lower extremities. , easy to use, but it is easy to cause postoperative bleeding tendency. Although low molecular weight heparin has a certain effect in preventing deep vein thrombosis of lower extremities, it has many contraindications, large side effects, and poor patient compliance, especially for epidural surgery. Greater risk of epidural hematoma during perineural procedures such as anesthesia

Method used

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preparation example Construction

[0055] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is an oral liquid, specifically:

[0056]The first step is to crush the angelica, jujube, Selaginella, saffron, Panax notoginseng, rhubarb, Qianjinba, Qianzhenwanxiancao, Guangxiangteng, wangbuliuxing and turmeric, and mix them by weight. The final powder is dissolved in ethanol with an alcohol concentration of 70% to 80%, soaked for 24 hours to 36 hours, and slowly percolated at a rate of 2 to 4ml per minute by the percolation method, and the percolation liquid is collected, and the added ethanol The mass of the mixed powder is 5-8 times that of the mixed powder, concentrated under reduced pressure to 1 / 10 of the original volume, centrifuged to obtain the centrifuged supernatant, and the supernatant is absorbed by a macroporous resin column, and firstly used relative to the first step obtained Wash with 2...

Embodiment 1

[0064] The preparation of embodiment 1 oral liquid 1

[0065] Grind 55g of angelica, 40g of jujube, 20g of Selaginella, 25g of saffron, 40g of notoginseng, 25g of Rhizoma rhubarb, 30g of Qianjinba, 20g of Herba chinensis, 40g of Guangxiangteng, 25g of wangbuliuxing and 30g of turmeric , mixed, the mixed powder was dissolved in 2kg of ethanol with an alcohol concentration of 70%, soaked for 24 hours, slowly percolated at a speed of 4ml per minute by percolation method, collected percolation liquid, concentrated under reduced pressure to the original volume 1 / 10, centrifuged to obtain the supernatant, the supernatant was absorbed by a macroporous resin column, first eluted with 1kg of water and discarded, then eluted with gradient ethanol, and washed with 1.3kg of alcohol concentration 50% ethanol for the first time Take off, then elute with 2.2kg alcohol concentration 80% ethanol, merge gradient ethanol eluent, reclaim ethanol under reduced pressure, obtain clear ointment, the ...

Embodiment 2

[0066] The preparation of embodiment 2 oral liquid 2

[0067] Grind 60g of angelica, 45g of jujube, 25g of Selaginella, 30g of saffron, 45g of Panax notoginseng, 30g of Rhizoma rhubarb, 35g of Qianjinba, 25g of scutellaria chinensis, 45g of vine, 30g of wangbuliuxing and 35g of turmeric , mixed, the mixed powder was dissolved in 2.5kg of ethanol with an alcohol concentration of 70%, soaked for 24 hours, slowly percolated at a rate of 4ml per minute by percolation method, collected percolation liquid, concentrated under reduced pressure to the original 1 / 10 of the volume, centrifuged to obtain the supernatant, the supernatant was absorbed by a macroporous resin column, first eluted with 1.5kg of water and discarded, and then eluted with gradient ethanol, the first time with 1.8kg of alcohol with a concentration of 50% Elution with ethanol, then elution with 2.5kg alcohol concentration 80% ethanol, combined gradient ethanol eluent, reclaimed ethanol under reduced pressure, to ob...

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Abstract

The invention provides a Chinese medicinal composition for preventing lower extremity deep vein thrombosis after hip replacement. The Chinese medicinal composition comprises the following crude medicaments: Chinese angelica, jujubes, selaginella, saffron, Indian buead, pseudo-ginseng, clematis root, Chinese thorowax root, cassia twig, yam, heterophylly falsestarwort root, companumoea root, galanga resurrectionlily rhizome, franzenbach rhubarb root and rhizome, moghania philippinensis, stellaria yunnanensis, root-bark of manybract fissistigma, cowherb seeds, dogwood, manyprickle acanthopanax root, cistanche and turmeric. The Chinese medicinal composition has the effects of promoting blood circulation to remove blood stasis and relieving swelling and pain, and has remarkable prevention effects and high safety, thereby being an orthopedic post-operative medicament with high clinical popularization and application value.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing deep vein thrombosis of lower limbs after hip joint replacement. Background technique [0002] With the continuous maturity of hip arthroplasty, it has increasingly become the primary means of clinical treatment of femoral neck fractures, femoral head necrosis, osteoarthritis and other femoral diseases, and has gradually been accepted and promoted by patients and medical workers. However, the formation of deep venous thrombosis in the lower extremities seriously affects the recovery of patients after operation, and even endangers the lives of patients. At present, reports of lower extremity deep vein thrombosis after hip replacement have attracted more and more attention. [0003] The mechanism of thrombus formation mainly includes the following aspects: surgery itself is a kind of trauma, which cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/08A61K9/16A61P7/02A61P29/00
Inventor 丁飞王静牟雪梅张治成
Owner 丁飞
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