Lipid microsphere preparation and preparation method thereof
A technology of lipid microspheres and preparations, which is applied in the field of esterified lipid microsphere preparations, and can solve problems such as influence, side effects, and restrictions on popularization and application
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Embodiment 1
[0056] 1. Prescription composition
[0057] Element
Dosage
effect
Propofol
10g
drug
flurbiprofen axetil
10g
drug
Refined egg yolk lecithin
12g
Emulsifier
Refined soybean oil
100g
Oil phase solvent
Glycerin
22.5g
osmotic regulator
Oleic acid
0.3g
stabilizer
sodium hydroxide
Appropriate amount
pH regulator
Water for Injection
Dilute to 1000ml
solvent
[0058] 2. Preparation process
[0059] (1) Preparation of the oil phase: Take the prescribed amount of refined egg yolk lecithin (Germany Lipoid Company), refined soybean oil (Tieling Beiya Pharmaceutical Oil Co., Ltd.), oleic acid (Germany Lipoid Company) into the container, place Heating in a water bath at 70°C, high-shearing for 30 minutes to dissolve until clear, and make an oil phase, add the prescribed amount of propofol (Wuhan Daan Pharmaceutical Co., Ltd.), flurbiprofen axetil ...
Embodiment 2
[0067] The preparation method of this example is the same as that of Example 1, except that flurbiprofen axetil is replaced by an equivalent amount of flurbiprofen propionyloxymethyl ester (Wuhan Daan Pharmaceutical Co., Ltd.).
[0068] Encapsulation Efficiency Test of Liposphere Preparation
[0069] Determination of the encapsulation efficiency of propofol and flurbiprofen esterified products of the liposome preparations prepared in the above-mentioned examples 1 and 2, and carried out with the commercially available contrast preparations of propofol or flurbiprofen axetil Comparison (control preparation 1: propofol injection (10ml: 100mg), produced by Xi'an Libang Pharmaceutical Technology Co., Ltd.; control preparation 2: flurbiprofen axetil injection (5ml: 50mg), produced by Beijing Tide Pharmaceutical Co., Ltd.) .
[0070] (1) Liposphere supernatant: Precisely pipette 2.0 mL of the prepared liposphere preparation or control preparation, place in a micro ultracentrifuge, ...
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