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1,7-Meta-dicarbadecaborane diformic acid-triphenyltin chloride complex, as well as preparation method and application thereof

A technology of triphenyltin dicarboxylate and meta-decaborane, which is applied in tin organic compounds, drug combinations, antineoplastic drugs, etc., to achieve low cost, high anticancer activity, and good fat solubility

Inactive Publication Date: 2014-04-09
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on organotin complexes of dicarbadecaborane dicarboxylate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 0.1 mmol m-C 4 B 10 h 12 o 4 Dissolve in 15 mL CH 3 CH 2 OH, after 15 min, add 0.1 mmol Ph 3 SnCl, stirred and reacted for 8 h, then added 0.1 mmol 2,2'-bipyridine to the above mixed solution, and continued to stir for 4 h. After the reaction was completed, it was filtered to obtain a pale pink solution, and the filtrate was naturally volatilized at room temperature, and after three weeks, pink crystals of 1,7-m-dicarbocaboranedicarboxylic acid triphenyltin chloride complex were obtained. The melting point of the target product is 224℃, and the yield is 68.6%.

[0019] The 1,7-m-dicarbadecaboranedicarboxylic acid triphenyltin chloride complex of the present invention is analyzed by X-single crystal diffraction, and the crystallographic data are as follows: the compound belongs to the monoclinic crystal system, and the space group is P2 1 / n , the cell parameters are: a = 11.3716(13)?, b = 16.7078(16)?, c = 19.0121(18)?, α = 90°, β = 89.8640(10)°, gam...

Embodiment 2

[0022] 0.1 mmol m-C 4 B 10 h 12 o 4 Dissolve in 15 mL CH 3 CH 2 OH, add 0.1 mmol Ph 3SnCl, after stirring for 2 h, 0.1 mmol 2,2'-bipyridine was added to the above mixed solution, and the stirring was continued for 4 h. After the reaction was completed, it was filtered to obtain a light pink solution, and the filtrate was naturally volatilized at room temperature. After three weeks, pink crystals were obtained with a melting point of 224° C. and a yield of 52.1%.

Embodiment 3

[0024] 0.1 mmol m-C 4 B 10 h 12 o 4 Dissolve in 15 mL CH 3 CH 2 OH, add 0.1 mmol Ph 3 SnCl, after stirring for 4 h, add 0.1 mmol 2,2'-bipyridine to the above mixed solution, and continue stirring for 4 h. After the reaction was completed, it was filtered to obtain a pale pink solution. The filtrate was naturally volatilized at room temperature, and after three weeks, pink crystals were obtained with a melting point of 224° C. and a yield of 56.3%.

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Abstract

The invention provides a 1,7-meta-dicarbadecaborane diformic acid-triphenyltin chloride complex, as well as a preparation method and application of the 1,7-meta-dicarbadecaborane diformic acid-triphenyltin chloride complex. The molecular formula of the 1,7-meta-dicarbadecaborane diformic acid-triphenyltin chloride complex is {[(Ph3Sn)(m-CDC)}.(2,2'-Bipyridine)}n(m-CDCH2=1,7-meta-dicarbadecaborane diformic acid; the 1,7-meta-dicarbadecaborane diformic acid-triphenyltin chloride complex has high antitumor activity and can be taken as the raw material to prepare drugs for treating leukemia, human colon cancer and human colorectal adenocarcinoma. Compared with the platinum type anti-cancer drugs commonly used at present, the organic tin complex provided by the invention has the advantages such as high antitumor activity, good lipid solubility, low cost and simple preparation method; and as a result, a new thinking and a new method are provided for developing anticancer drugs.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a preparation method of 1,7-m-dicarbadecaborane dicarboxylic acid triphenyltin chloride coordination compound and its application in anticancer drugs. Background technique [0002] Organotin is a kind of metal-organic compound that has been studied more actively in recent years, and is widely used in plastic stabilization, sterilization, wood preservation, and marine antifouling. In 1972, organotin carboxylic acid complex Ph 3 SnOOCCH 3 It was found to have anticancer activity. Since then, organotin carboxylic acid compounds have attracted widespread attention, and a variety of organotin coordination compounds with good anticancer activity have also been reported. [0003] Borane derivatives are mainly used in boron neutron capture therapy and have selective affinity for certain cancer cells in the human body. Currently reported more borane derivatives are mainly o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F7/22A61P35/00A61P35/02
Inventor 李士帅李大成窦建民
Owner LIAOCHENG UNIV
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