A tumor marker and its application in the preparation of colorectal cancer diagnostic reagents

A technology of colorectal cancer and diagnostic reagents, applied in the field of serum/tissue tumor markers, can solve problems such as low sensitivity, failure to achieve diagnosis, and inaccurate indicators of pancreatic cancer
CN103740854BActive Publication Date: 2015-10-21THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Publication Date
2015-10-21

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Abstract

The invention belongs to the field of genetic engineering and medicines, and relates to a novel tumor marker for early diagnosis of colorectal cancer, in particular to a tumor marker related to the colorectal cancer and application thereof. The marker is a composition of CystatinSN (CST1), CystatinS (CST4) and CystatinSA (CST2). The marker as well as a primer and an antibody thereof can be applied to a diagnostic kit for the auxiliary diagnosis of the colorectal cancer.
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Description

technical field

[0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a serum / tissue tumor marker related to colorectal cancer and its application. Background technique

[0002] Colon cancer and rectal cancer are common malignant tumors, most of them are advanced, and their incidence rate ranks fourth among malignant tumors. With economic development, changes in lifestyle, living environment and dietary structure, the incidence of colorectal cancer is on the rise. Although the diagnostic level of colorectal cancer has improved, the detection rate of early colorectal cancer is still low and the mortality rate is high. According to statistics, the 5-year survival rate of early colon cancer after radical surgery is about 80%, while the 5-year survival rate of advanced colon cancer is only 50%. Therefore, early diagnosis is a key factor in improving the cure rate of colon cancer, and finding tumor markers with high sensitivity and speci...

Claims

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