Bioabsorbable microclips and applicators for minimally invasive surgical wound closure
A micro-clip, biological technology, applied in surgery, wound clips, medical science, etc., can solve the problems of increasing the formation of scar tissue, hindering the proper fixation of tissues, and low tensile strength
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Embodiment 1
[0063] Degradation of Bioabsorbable Wound Closure Clips
[0064] Bioabsorbable wound closure clips made of 99.5% magnesium (Sigma Aldrich, 13103) 20 pcs. Polycaprolactone (PCL) with an average molecular weight of 80000 (Sigma Aldrich, 440744) was covered on 10 bioabsorbable wound closure clips as follows: 3% PCL w / v in dichloromethane
[0065] Ten magnesium bioabsorbable wound closure clips were soaked in PCL solution for 45 s and then air-dried at room temperature.
[0066] The steps of immersion degradation in artificial salt water are as follows:
[0067] Artificial saline = 10:1 concentration of phosphate buffered saline (PBS; Sigma Aldrich) and xanthan gum at a concentration of 0.92 grams per liter (g / l);
[0068] The concentration of table salt (sodium chloride) was maintained at 8 g / l.
[0069] Mg and Mg-PCL samples were suspended in the separation solution with an initial pH of 7.36.
[0070] After soaking for two weeks, dry in the atmosphere for 48 hours. as in...
Embodiment 2
[0072] Wound Closure Clip Application and Strength
[0073] A longitudinal incision was made on one or both vocal cords of the larynx of the pig carcass to form an epithelial flap. The bioabsorbable wound closure clip is placed on a surgical device and inserted through a laryngoscope and guided through an operating microscope. Surgical equipment was used to deploy and deform 3 to 5 bioabsorbable wound closure clips in each larynx.
[0074] Evaluation of wound strength was determined based on vibration. During surgery, the larynx of the cadaver is fixed on a frame, and the vocal cords are positioned opposite each other to simulate adduction of the vocal cords during vocalization. Air is infused from below through the trachea to simulate air pressure at the glottis and induce vibration of the vocal cords.
[0075] Evaluate the performance of bioabsorbable wound closure clips to hold securely under constant traction or vibration. The bioabsorbable wound closure clips were f...
Embodiment 3
[0077] in vivo biocompatibility
[0078] Bioabsorbable wound closure clips are prepared in the form of clips. The thickness of the clip is between 0.35mm and 0.2mm. The 5 prepared clips are as follows:
[0079] Type 1: Unpolished 99.5% magnesium, eight clips 0.35mm thick.
[0080] Type 2: Polished 99.5% magnesium, four clips with a thickness of 0.35mm.
[0081] Type 3: Polished 99.5% magnesium, three clips with a thickness of 0.25mm.
[0082] Type 4: Polished 99.5% magnesium, 8 clips with a thickness of 0.2mm.
[0083] Type 5: Four clips of polished 99.5% magnesium, 0.2 mm thick, PCL clad as described in Example 1 above.
[0084] Polished clips are sanded with 2000-grit silicon carbide sandpaper. Five anesthetized pigs were positioned supine with slight cervical spine flexion. Insert the laryngoscope. The application of bioabsorbable wound closure clips in pigs 1 to 5 is described in the table below.
[0085]
PUM
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