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Method for purifying carabrone

A technology of Tianmingjing lactone and a purification method, which is applied in the field of purification of Tianmingjinglactone, can solve the problem of low purity of Tianmingjinglactone, and achieve the effect of simple operation and high purity

Inactive Publication Date: 2014-05-14
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a method for purifying astragalactone in order to overcome the defect that the purity of astragalactone is not high in the existing method for purifying astragalactone

Method used

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  • Method for purifying carabrone
  • Method for purifying carabrone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation process of Tianmingjing lactone ketone is a process of extracting and separating Tianmingjing lactone ketone using the northern crane locust as raw material and 0.5% NaOH solution as the extraction agent. The specific steps are as follows:

[0023] (1) Take 1kg of the northern crane lice, use 5L 0.5% (w / w) NaOH solution, ultrasonically treat at 30°C for 30 minutes, separate the northern crane lice with 200 mesh filter cloth, and then use 4L 0.5% (w / w) NaOH The solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth; then 3L of 0.5% (w / w) NaOH solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth ; Combine the extracts extracted three times.

[0024] (2) Add 1% (w / w) hydrochloric acid solution to the extract to neutralize at room temperature (25°C), adjust the pH to about 3, produce a precipitate, and let ...

Embodiment 2

[0031] (1) Take 5kg of northern crane lice, use 20L 1% (w / w) NaOH solution, ultrasonically treat at 30°C for 30 minutes, separate the northern crane lice with 200 mesh filter cloth, and then use 15L 1% (w / w) NaOH The solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth; then 10L of 1% (w / w) NaOH solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth ; Combine the extracts extracted three times.

[0032] (2) Add 3% (w / w) hydrochloric acid solution to the extract to neutralize at room temperature (25°C), adjust the pH to about 2, produce a precipitate, and let it stand.

[0033] (3) Separate the precipitated bottom from the supernatant, repeat steps (1) and (2) for the precipitated precipitate; add 2.5L ethyl acetate to the supernatant for extraction, extract three times, combine the three extracts, and concentrate.

[0034] (...

Embodiment 3

[0039] (1) Take 10kg of northern crane lice, use 25L 2% (w / w) NaOH solution, ultrasonically treat at 30°C for 30 minutes, separate the northern crane lice with 200-mesh filter cloth, and then use 20L 2% (w / w) NaOH The solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth; then 15L of 2% (w / w) NaOH solution was ultrasonically treated at 30°C for 30 minutes, and the northern crane lice was separated with a 200-mesh filter cloth ; Combine the extracts extracted three times.

[0040] (2) Add 6% (w / w) hydrochloric acid solution to the extract filtrate of the northern crane lice, neutralize it at room temperature (25°C), adjust the pH to about 1, produce a precipitate, and let it stand.

[0041] (3) Separate the precipitated bottom from the supernatant, and repeat steps (1) and (2) for the precipitation; add 4L ethyl acetate to the supernatant for extraction, extract three times, combine the three extracts,...

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Abstract

The invention discloses a method for purifying carabrone. The method comprises the following steps: (1) soaking or ultrasonically extracting carpesium abrotanoides in a water solution of inorganic strong base at 0-100 DEG C; then, filtering, adjusting the pH value of filter liquor to be 1-7 by the inorganic strong base to generate deposits; (2) removing the deposits generated in the step (1), and then extracting supernatant liquid by an organic solvent to obtain extracting liquid; and (3) performing silica column chromatography on the extracting liquid obtained from the step (2) to obtain the carabrone. The method is easy to operate; the obtained carabrone is relatively high in purity.

Description

technical field [0001] The present invention specifically relates to a method for purifying Tianmingjing lactone. Background technique [0002] The northern crane louse is the dried and ripe fruit of Tianmingjing, a plant in the Compositae family. It has the effect of killing insects and eliminating accumulation. It is often used to treat roundworms, pinworms, tapeworms, abdominal pain caused by insect accumulation, and malnutrition in children. There are relatively few studies on the chemical constituents of the northern crane lice in this field. The current research shows that the northern crane lice contain tellolide (Liu Cuizhou, Xu Jing, Gui Liping, etc. Research on the chemical components of the northern crane lice[J]. Drug Evaluation Research, 2010,33(6):220-221), Tianmingjing lactone ketone, Tianmingjinglactone alcohol and various fatty acids. Studies have shown that Tianmingjing lactone is a sesquiterpene compound with bactericidal and bacteriostatic effects. In or...

Claims

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Application Information

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IPC IPC(8): C07D307/93
CPCC07D307/77
Inventor 段金友崔国庭张阿敏张武霞母海钵张琳牛红王清洁董冬旗
Owner NORTHWEST A & F UNIV
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