Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Direct sample analysis ion source

An ion source and sample technology, applied in particle separation tubes, separation tube vacuum systems, sample introduction/extraction, etc.

Active Publication Date: 2014-05-14
PERKINELMER HEALTH SCIENCES INC
View PDF7 Cites 25 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Additionally, existing ambient atmospheric ion sources have been configured to accommodate only a single type of solid, liquid, or gas sample

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Direct sample analysis ion source
  • Direct sample analysis ion source
  • Direct sample analysis ion source

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0072] Open ion sources configured for direct analysis of samples are subject to variations in background air composition and expose the end user to the sample to be analyzed and to any reagent species configured in the analysis. Gaseous reagent species and volatilized sample material may be drawn in by the end user running the assay. This exposure can be particularly dangerous when analyzing drugs, newly synthesized compounds, medicinal samples, diseased tissue, toxic substances or even unknown samples as in forensic samples for which there is no available history. When operating an open ion source, changes in background gas composition can affect ionization efficiency, contribute to background contamination, add interfering component peaks to the mass spectrum, and unpredictably change reagent ion composition and temperature, leading to unpredictable analytical results . The present disclosure features devices and methods that allow analysis of multiple samples introduced d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and / or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.

Description

technical field [0001] The present disclosure relates to a direct sample analysis system that includes an ion source operating at atmospheric pressure and connected to a mass spectrometer or other gas phase detector. This ion source can generate ions from multiple samples with a wide variety of properties that are introduced directly into the direct sample analysis system ion source. Background technique [0002] In recent years there has been rapid growth in the prevalence and diversification of techniques for desorbing and ionizing sample species from solid surfaces under ambient atmospheric conditions without significant sample preparation and subsequent chemical analysis by mass spectrometry. Examples of such techniques include, but are not limited to: "Desorption Electrospray Ionization" (DESI); "Thermal Desorption Atmospheric Pressure Chemical Ionization" (TD / APCI); "Direct Analysis in Real Time" (DART); "Desorption Atmospheric Pressure Chemical Ionization" ( DAPCI) a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04
CPCH01J49/0413H01J49/0431H01J49/0459H01J49/145H01J49/24
Inventor C.M.怀特豪斯
Owner PERKINELMER HEALTH SCIENCES INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com