Direct sample analysis ion source

An ion source and sample technology, applied in particle separation tubes, separation tube vacuum systems, sample introduction/extraction, etc.

Active Publication Date: 2014-05-14
PERKINELMER HEALTH SCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Additionally, existing ambient atmospheric ion sources have been configured to accommodate only a single type of solid, liquid, or gas sample

Method used

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  • Direct sample analysis ion source
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Embodiment Construction

[0072] Open ion sources configured for direct analysis of samples are subject to variations in background air composition and expose the end user to the sample to be analyzed and to any reagent species configured in the analysis. Gaseous reagent species and volatilized sample material may be drawn in by the end user running the assay. This exposure can be particularly dangerous when analyzing drugs, newly synthesized compounds, medicinal samples, diseased tissue, toxic substances or even unknown samples as in forensic samples for which there is no available history. When operating an open ion source, changes in background gas composition can affect ionization efficiency, contribute to background contamination, add interfering component peaks to the mass spectrum, and unpredictably change reagent ion composition and temperature, leading to unpredictable analytical results . The present disclosure features devices and methods that allow analysis of multiple samples introduced d...

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Abstract

A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and / or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.

Description

technical field [0001] The present disclosure relates to a direct sample analysis system that includes an ion source operating at atmospheric pressure and connected to a mass spectrometer or other gas phase detector. This ion source can generate ions from multiple samples with a wide variety of properties that are introduced directly into the direct sample analysis system ion source. Background technique [0002] In recent years there has been rapid growth in the prevalence and diversification of techniques for desorbing and ionizing sample species from solid surfaces under ambient atmospheric conditions without significant sample preparation and subsequent chemical analysis by mass spectrometry. Examples of such techniques include, but are not limited to: "Desorption Electrospray Ionization" (DESI); "Thermal Desorption Atmospheric Pressure Chemical Ionization" (TD / APCI); "Direct Analysis in Real Time" (DART); "Desorption Atmospheric Pressure Chemical Ionization" ( DAPCI) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04
CPCH01J49/0413H01J49/0431H01J49/0459H01J49/145H01J49/24
Inventor C.M.怀特豪斯
Owner PERKINELMER HEALTH SCIENCES INC
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