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Tissue engineering tendon scaffold reinforcement with square meshed structure

A technology of tissue engineering and stent reinforcement, which is applied in the field of medical devices, can solve the problems of large extensibility, and achieve the effects of low axial elongation, stable structure, and large porosity

Inactive Publication Date: 2014-05-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the deficiency of the above-mentioned tendon scaffold reinforcement is that the longitudinal (axial) direction is relatively extensible.

Method used

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  • Tissue engineering tendon scaffold reinforcement with square meshed structure
  • Tissue engineering tendon scaffold reinforcement with square meshed structure
  • Tissue engineering tendon scaffold reinforcement with square meshed structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] figure 1 It is a schematic diagram of the appearance structure of the tissue-engineered tendon scaffold reinforcement with a square mesh structure in this embodiment, and the preparation method of the tissue-engineered tendon scaffold reinforcement with a square mesh structure is as follows:

[0020] (1) Choose 8.78tex / 12f polyglycolic acid (Polyglatic Acid, PGA) fiber filament and 6.17tex / 24f polylactic acid (PolyLactic Acid, PLA) fiber filament, with 3 PGA fiber filaments and 2 PLA Fibrous filaments are braided on a 6-spindle braiding machine to obtain a braided wire diameter of 0.197mm.

[0021] (2) Select the braided thread prepared in step (1) for use, press figure 2 The structure shown (three-needle braiding needle 1 + one long needle 2) is hand-knitted to form a rectangular grid mesh structure, and braiding needle 1 and long needle 2 form the two sides of the rectangular grid mesh, and each rectangular grid mesh The hole loops are connected to make image 3 T...

Embodiment 2

[0027] The preparation method of the tissue engineering tendon scaffold reinforcement with square mesh structure is as follows:

[0028] (1) Choose 8.78tex / 12f polyglycolic acid (Polyglatic Acid, PGA) fiber filament and 6.17tex / 24f polylactic acid (PolyLactic Acid, PLA) fiber filament, with 2 PGA fiber filaments and 1 PLA Fibrous filaments are braided on a 3-spindle braiding machine to obtain a braided wire diameter of 0.155mm.

[0029] (2) Select the braided thread prepared in step (1) for use, press figure 2 The structure shown (three-needle braiding needle 1 + one long needle 2) is hand-knitted to form a rectangular grid mesh structure, and braiding needle 1 and long needle 2 form the two sides of the rectangular grid mesh, and each rectangular grid mesh The hole loops are connected to make image 3 The shown circular cylindrical hollow ring structure has 6 rectangular grid holes, an inner diameter of 8.5 mm, a thickness of 0.9 mm, and a length of 30 mm.

[0030] Throug...

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Abstract

The invention provides a tissue engineering tendon scaffold reinforcement with a square meshed structure. The reinforcement is made of woven lines woven by a spindle knitter from polyglycolic acid fiber filament and polylactic acid fiber filament according to the mass ratio of (70-99):(30-1); the tissue engineering tendon scaffold reinforcement is a fabric with cylindrical grid meshed annular structure, woven by the woven lines; the cylindrical grid meshed annular structure is a hollow annular structure formed in the way that a rectangular grid meshed structure is formed by weaving the woven lines, braid stitches and long stitches form two side columns of rectangular grid meshes, the rectangular grid meshes are connected in a circulating manner, and 4-10 rectangular grid meshes are arranged in the peripheral direction. The tissue engineering tendon scaffold reinforcement provided by the invention has stronger tensile strength, and is stable in structure, high in porosity, low in axial ductility, and controllable in degradation rate.

Description

technical field [0001] The invention relates to a tissue engineering tendon support, in particular to a biodegradable tissue engineering tendon support reinforcement, which belongs to the technical field of medical devices. Background technique [0002] Tendon defect is one of the common diseases in clinic. At present, tissue engineering technology is being used to improve artificial tendon at home and abroad. The three elements of tissue engineering include: cells, scaffolds and growth factors. As one of the three major elements, the scaffold must have the following characteristics: ①Good biocompatibility and non-toxicity; ②Appropriate three-dimensional shape; ③High pores with good connectivity between pores and suitable caliber; ④Appropriate surface Morphological and chemical properties; ⑤ correct fiber orientation, large specific surface area; ⑥ scaffold degradation should be suitable for tissue formation rate, so that the mechanical properties of the scaffold match the ...

Claims

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Application Information

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IPC IPC(8): A61L27/18D04C1/02D04C1/06D04C1/12
Inventor 张佩华龚泽罗云蔚何孜晗杨庆郯志清郭正
Owner DONGHUA UNIV
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