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Composite Chinese pulsatilla root granular preparation, and preparation method thereof

A Pulsatilla and granule technology, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, bulk delivery, etc., can solve the problems of increasing the burden of patients suffering from medical staff, and inconvenient use of Pulsatilla decoction.

Inactive Publication Date: 2014-06-04
QINGDAO KDN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But common Pulsatilla decoction decoction appears to be inconvenient to use in clinical application, and medicine is easily absorbed and decomposed before reaching colon after oral administration of Pulsatillae decoction, and rectal (enema or suppository) administration also can't reach colon, and increases patient's misery and medical service Disadvantages such as the burden of personnel

Method used

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Examples

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preparation example Construction

[0006] The preparation method step of compound pulsatilla granule in the present invention is as follows:

[0007] 1. According to the weight ratio of the formula, 4 parts of Pulsatilla chinensis, 2 parts of Cortex Phellodendri, 3 parts of Coptidis Rhizoma, and 4 parts of Qinpi. Weigh the above 4 herbs and crush them into small pieces;

[0008] 2. Each time add 10 times the amount of water and reflux extraction 3 times, 2h / time;

[0009] 3. Concentrate and dry the extract, add auxiliary materials, pulverize and granulate.

[0010] The present invention is further illustrated below in conjunction with specific examples.

Embodiment 1

[0012] Four medicinal materials such as Pulsatilla grandis, Coptis chinensis, Cortex Phellodendron, and Cortex chinensis were taken by weight in proportion to the formula, crushed into small pieces, mixed and extracted 3 times, adding water 10 times each time (parts by weight, the same below), reflux extraction for 2 hours, and filtering. The combined filtrates were set aside for later use.

[0013] The extract is concentrated to a relative density of 1.10, and the concentrate is dried and pulverized. Add appropriate amount of starch and mix to make granulated finished product.

Embodiment 2

[0015] Weigh the four medicinal materials of Pulsatilla pulsatillae, Coptis chinensis, Cortex Phellodendron, and Cortex chinensis in parts by weight of the formula, crush them into small pieces, mix and extract 3 times, add water 10 times, extract under reflux for 2.0 hours, filter, and combine the filtrates to stand for later use.

[0016] The extract is concentrated to a relative density of 1.15, and the concentrate is dried and pulverized. Add appropriate amount of dextrin and mix to make granulated finished product.

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Abstract

The invention belongs to the technical field of veterinary drug, and discloses a composite Chinese pulsatilla root granular preparation, and a preparation method thereof. According to the preparation method, 4 Chinese herbal medicine ingredients, Chinese pulsatilla root, coptis chinensis, cortex phellodendri, and cortex fraxini are smashed, are subjected to reflux extraction, and then are condensed so as to obtain a fluid extract; the fluid extract is dried, and is mixed with auxiliary materials so as to obtain the composite Chinese pulsatilla root granular preparation. The composite Chinese pulsatilla root granular preparation is obtained on the base of boiling decoction extraction method of traditional decoction, and via improvement of extraction technology; dosage is reduced; and quality is improved.

Description

technical field [0001] The invention belongs to the field of veterinary antidiarrheal preparations, and relates to a pulsatilla granule and a preparation method thereof. Background technique [0002] Piglet pullorum is an intestinal infectious disease characterized by diarrhea of ​​milky white fishy feces in suckling piglets. The disease is mainly caused by pathogenic Escherichia coli, and the pathogen is infected through the digestive tract. It is a common and frequently-occurring disease of piglets, and pullorum of piglets has occurred in almost all pig farms. The disease can occur throughout the year, but it is more common in early spring, severe winter and hot summer. It is one of several major diseases that plague breeders. [0003] The prescription of compound Pulsatilla granules is derived from Pulsatilla Decoction in Treatise on Febrile Diseases. It is composed of four herbs: Pulsatillae, Coptidis, Cortex Phellodendri and Qinpi. It has the effects of clearing heat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/16A61P1/12A61P31/04
Inventor 郝智慧杨芬芳刘元元
Owner QINGDAO KDN BIOTECH
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