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Functionalized starch matrix hollow capsule

A technology of starch matrix and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, and food forming, etc. It can solve problems such as long disintegration time, easy brittle capsules, and unsatisfactory physical and chemical properties. Improve the ability to resist hypoxia, reduce blood viscosity, and promote the effect of rehabilitation adjustment

Active Publication Date: 2014-06-04
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also reports in the literature that the disintegration time of this type of capsule is relatively long, and the physical and chemical properties of the capsule are easy to become brittle at low temperature, and storage at a temperature above 30°C is still unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Mix 50g of hydroxypropyl wheat starch and 50g of locust bean gum and lentinan (wherein the content of lentinan in the composition is 1wt%) to obtain the basic raw material for preparing hollow capsules, and then use traditional dipping The hollow capsules are prepared by glue technology, and the functional starch matrix hollow capsules are prepared. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010. The friability was detected by polytetrafluoroethylene weights. 50 samples were broken and 3 capsules were broken. The crushing degree can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for the disintegration experiment, and all the test samples can be completely disintegrated within 10 minutes, and the disintegration time limit meets the requirements of the Pharmacopoeia.

Embodiment 2

[0019] The composition of 70g of hydroxymethyl wheat starch and 30g of locust bean gum and lentinan (wherein the content of lentinan in the composition is 2wt%) is mixed to obtain the basic raw material for preparing hollow capsules, and then adopt traditional dipping The hollow capsules are prepared by glue technology, and the functional starch matrix hollow capsules are prepared. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010. The friability was detected by polytetrafluoroethylene weights. 50 samples were broken and 2 capsules were broken. The crushing degree can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for the disintegration experiment, and all the test samples can be completely disintegrated within 10 minutes, and the disintegration time limit meets the requirements...

Embodiment 3

[0021] The composition of 80g of hydroxypropyl bean starch and 20g of locust bean gum and lentinan (wherein the content of lentinan in the composition is 8wt%) is mixed to obtain the basic raw material for preparing hollow capsules, and then adopt traditional The hollow capsules are prepared by dipping in glue, and the functional starch-based hollow capsules are prepared. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The friability was detected by polytetrafluoroethylene weights. 50 samples were not broken, and their friability The speed can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for disintegration experiments, and the test samples can be completely disintegrated within 10 minutes, and the disintegration time limit meets the requirements of the Pharmacopoeia. ...

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PUM

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Abstract

The invention relates to a capsule widely used in drug, health-care products and food industries, and particularly relates to a functionalized starch matrix hollow capsule. The functionalized starch matrix hollow capsule is prepared from the raw material of the functionalized starch matrix hollow capsule by a conventional technology, wherein the raw material of the functionalized starch matrix hollow capsule is a mixture of modified starch, which is used as a basic matrix, with locust bean gum and mushroom polysaccharide composition which are used as reinforcing and toughening gelatinizing agents. The mushroom polysaccharide and locust bean gum which have biofunctionability action are introduced in the formula of the hollow capsules; and due to the functionality of mushroom polysaccharide, the functionalized starch matrix hollow capsule has obvious functional characteristics which the existing gelatin hollow capsules do not have. The functionalized starch matrix hollow capsule can be widely used in medicine, health-care product and food industries.

Description

technical field [0001] The invention relates to capsules widely used in medicine, health products and food industries, in particular to functional starch-based hollow capsules. Background technique [0002] It has a long history to prepare medicinal empty capsules by using gelatin hydrolyzed from collagen in animal skin and bone tissue, because the medicinal ingredients wrapped in hollow capsules can avoid the stimulation of the drug itself to the sensory organs of the human body, and achieve The slow-release effect of drugs in the body has long been widely used in the fields of medicine and food by hollow capsules made of gelatin. As the main encapsulation material for medicines and health care products, its defects are also recognized by everyone. Such as its own protein is easily affected by acid and alkali, which limits the use of certain drugs. Gelatin molecules contain more active groups, which are easy to react with the drugs in contact, thus changing the properties...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48A23P1/04C08L3/08C08L5/00A23P10/30
Inventor 袁国卿闫丰文闫芳
Owner INST OF CHEM CHINESE ACAD OF SCI
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