Functionalized starch matrix hollow capsule
A technology of starch matrix and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, and food forming, etc. It can solve problems such as long disintegration time, easy brittle capsules, and unsatisfactory physical and chemical properties. Improve the ability to resist hypoxia, reduce blood viscosity, and promote the effect of rehabilitation adjustment
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Example Embodiment
[0016] Example 1
[0017] Mix 50g of hydroxypropyl wheat starch and 50g of a combination of locust bean gum and lentinan (wherein the content of lentinan in the composition is 1wt%) to obtain the basic raw material for preparing hollow capsules, and then use traditional dip The gel process is performed to prepare hollow capsules, and functional starch-based hollow capsules are prepared. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method specified in the 2010 edition of the Chinese Pharmacopoeia. Teflon weights were used to test the friability. 50 samples were broken and 3 were broken. The fragmentation can meet the requirements of the pharmacopoeia; the Tianda Tianfa ZB-lE intelligent disintegrator is used for the disintegration experiment. The test samples can all disintegrate within 10 minutes, and the disintegration time limit meets the requirements of the pharmacopoeia.
Example Embodiment
[0018] Example 2
[0019] Mix 70g of hydroxymethyl wheat starch and 30g of a combination of locust bean gum and lentinan (wherein the content of lentinan in the composition is 2wt%) to obtain the basic raw material for preparing hollow capsules, and then use traditional dip The gel process is performed to prepare hollow capsules, and functional starch-based hollow capsules are prepared. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method specified in the 2010 edition of the Chinese Pharmacopoeia. The friability was tested with a polytetrafluoroethylene weight. 50 samples were broken and 2 were broken. Fragmentation can meet the requirements of the Pharmacopoeia; the Tianda Tianfa ZB-lE intelligent disintegrator is used for the disintegration experiment, and the test samples can all disintegrate within 10 minutes, and the disintegration time limit meets the requirements of the Pharmacopoeia.
Example Embodiment
[0020] Example 3
[0021] Mix 80g of hydroxypropyl bean starch and 20g of locust bean gum and lentinan composition (wherein the content of lentinan in the composition is 8wt%) to obtain the basic raw material for preparing hollow capsules, and then use traditional The dipping process is performed to prepare hollow capsules to obtain functional starch-based hollow capsules. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method specified in the 2010 edition of the Chinese Pharmacopoeia. The friability was tested with a polytetrafluoroethylene weight. 50 samples were not broken, but they were fragile. The degree can meet the requirements of the pharmacopoeia; the Tianda Tianfa ZB-lE intelligent disintegrator is used for the disintegration experiment. The test samples can all disintegrate within 10 minutes, and the disintegration time limit meets the requirements of the pharmacopoeia.
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