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A kind of ophthalmic pharmaceutical composition containing sirolimus

A composition and drug technology, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as adverse reactions and unsatisfactory drug effects, and achieve the effect of less adverse reactions

Inactive Publication Date: 2016-03-16
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] The inventor's Chinese patent applications No. 201210188186.9 and No. 201210188187.3 are based on the significant immunosuppressive effect of sirolimus in organ transplant patients, using a sustained release system to prepare sirolimus eye drops for the treatment of uvea Inflammation, although it has a certain curative effect, its efficacy is not ideal, and there are many adverse reactions

Method used

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  • A kind of ophthalmic pharmaceutical composition containing sirolimus
  • A kind of ophthalmic pharmaceutical composition containing sirolimus
  • A kind of ophthalmic pharmaceutical composition containing sirolimus

Examples

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Embodiment 7-9

[0031] Example 7-9 Preparation of Compound Sirolimus Ophthalmic Ointment

[0032] The used raw material components and consumption of preparation compound sirolimus eye ointment are as follows:

[0033] Preparation method: take a small amount of water for injection, first add co-solvent, add sirolimus, astragalus polysaccharide, sodium tanshinone ⅡA sulfonate and rehmannia glutinosa extract, stir to dissolve, filter aseptically; add appropriate amount of sterilized and cooled liquid paraffin , grind into a fine paste, pass through a 200-mesh sieve, then gradually add sterile and filtered lanolin and yellow petrolatum mixture, mix well, and obtain.

[0034] According to the technical solution of the present invention, the types of excipients that can be used to prepare sirolimus ophthalmic preparations are not limited to those listed in the above table, and the following multiple options can also be selected.

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Abstract

The invention discloses an ophthalmic pharmaceutical composition containing sirolimus, which includes sirolimus, astragalus polysaccharide, sodium tanshinone IIA sulfonate and rehmannia glutinosa extract, and is prepared according to a common method. The preparation for external use on the eye is suitable for treating ocular immune diseases such as uveitis and rejection after corneal transplantation. Compared with the common sirolimus ophthalmic preparation, it has better drug efficacy and less side effects.

Description

technical field [0001] The invention relates to medical preparations, in particular to pharmaceutical compositions for treating ocular immune diseases such as uveitis and rejection after corneal transplantation. Background technique [0002] Uveitis is a general term for a class of intraocular inflammatory diseases, including inflammation that occurs in the uvea, retina, retinal blood vessels, and vitreous body. It is a common blinding eye disease worldwide. Most uveitis is caused by immune mechanism, and its treatment mainly uses immunosuppressant, such as glucocorticoid. However, immunosuppressants are mostly used systemically, which can cause a variety of side effects, and some drugs also have hepatotoxicity, nephrotoxicity and gastrointestinal reactions. [0003] Graft rejection occurs in about 30% of corneal transplants, which is the main cause of corneal transplant failure. Hormone therapy and cyclosporine therapy have certain effects, but often cannot completely con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P27/02A61P37/06A61P37/02A61K31/436A61K31/715A61K31/58
Inventor 刘奕志王延东曾阳发刁红星
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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