Preparation method for 8-amino-5-methylquinoline
A technology of methylquinoline and amino, applied in the field of preparation of 8-amino-5-methylquinoline, which can solve the problems of long reaction time, high cost and high risk
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[0005] The preparation method of the 8-amino-5-methyl pyrine in the present invention is as follows:
[0006] 1. At room temperature, SNCL 2 · 2H 2 O is added to the ethyl acetate solution of 8-nitro-5-methyllyrine, stir 2-3 h;
[0007] 2. Use 10%sodium hydroxide solution to strong alkali;
[0008] 3. Sub-liquid, extract 2-3 times with ethyl acetate, combine organic phase, wash 2-3 times with saturated saline, dry sodium sulfate, filter, steam the dry solvent with a rotary evaporator;
[0009] 4. Reveals with a methanol water solution to obtain 8-amino-5-methyl pyrine.
[0010] The following is a combination of specific instances to further illustrate the present invention.
Embodiment 1
[0012] At room temperature, SNCL 2 · 2H 2 O (90 g, 4.2 EQ) is added to the 8-nitro-5-methyl acerne (18.0 g, 95.7 mmol) acetate solution of 330 ml and stir for 2-3 h.Use 10%sodium hydroxide solution to strong alkali, separate liquid, extract 2-3 times with ethyl acetate, combine organic phase, wash 2-3 times with saturated saline, dry sodium sulfate, filtrate, evaporate with rotation, evaporate with rotationThe instrument steamed dry solvents, the methanol solution was crystal, and the income yield was 100%.
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