Application of tetrandrine/dipotassium glycyrrhizinate in preparing anti-allergy drug

A technology of dipotassium glycyrrhizinate and tetrandrine, which is applied in the fields of drug combination, allergic diseases, and pharmaceutical formulations, etc.

Active Publication Date: 2014-07-09
SHANGHAI ZIBANG BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no supplementary use of tetrandrine and dipotassium glycyrrhizinate

Method used

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  • Application of tetrandrine/dipotassium glycyrrhizinate in preparing anti-allergy drug
  • Application of tetrandrine/dipotassium glycyrrhizinate in preparing anti-allergy drug
  • Application of tetrandrine/dipotassium glycyrrhizinate in preparing anti-allergy drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Raw materials: dipotassium glycyrrhizinate, purchased; tetrandrine powder, purchased from the market; 2, 4-dinitrochlorobenzene (DNCB), purchased from the market. Embodiment 1 skin anti-allergic animal test report

[0015] Abstract: After animals were exposed to 2,4-dinitrochlorobenzene (DNCB) through the skin, the anti-allergic effects of the test samples on the skin were observed. The results showed that: (tetrandrine / dipotassium glycyrrhizinate composition) has anti-allergic effect on animal skin.

[0016] 1.1 Purpose of the test:

[0017] After the skin of the guinea pig is induced by DNCB skin contact, an allergy (allergy) state occurs, and the test sample is applied at the same time, and the contact is stimulated, and the test is observed Antiallergic effect on the skin.

[0018] 1.2 Test material:

[0019] Test sample: (tetrandrine / dipotassium glycyrrhizinate=3:97) buy

[0020] (tetrametine) buy

[0021] (Dipotassium Glycyrrhizinate) buy

[0022] 2...

Embodiment 2

[0042] Embodiment 2 prepares skin care product " soothing cream "

[0043] All raw materials in the following formula are commercially available and prepared by conventional methods.

[0044] Soothing Cream

[0045]

[0046]

[0047] For allergic skin, the requirements for skin care products are very high, and the cosmetics of the present invention can be applied to sensitive skin for trial use.

[0048] Statistics of this product trial data:

[0049] 60 young women, 13-16 years old, 16-20 years old, 21-25 years old, 20 people in each trial, have sensitive skin, prone to acne and sores, and smearing skin care products on the face can easily cause rashes.

[0050] Trial method: send the present invention to the trial users at random, once in the morning and in the evening, according to the usual customary dosage. One month later, the results of the trial were revisited in the form of a questionnaire.

[0051] The trial results are as follows:

[0052] Table 2

[005...

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PUM

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Abstract

The invention relates to an application of tetrandrine/dipotassium glycyrrhizinate in preparing an anti-allergy drug and belongs to the field of drug compositions. With the adoption of the application, as the tetrandrine is assisted and matched with the dipotassium glycyrrhizinate, the antiallergic efficacy can be obviously improved; and cosmetics and skin care products prepared by adopting the drug composition are good in the allergy resistance and are suitable for persons with a sensitive skin.

Description

technical field [0001] The invention belongs to the field of chemical drugs, in particular to the application of the chemical drug composition tetrandrine / dipotassium glycyrrhizinate in the preparation of antiallergic drugs. Background technique [0002] Tetrandrine (Tetrandrine) mainly exists in the roots of Tetrandrine, a plant of the Tetradaceae family. It is a bisbenzylisoquinoline derivative, a colorless needle crystal (ether), almost insoluble in water, petroleum ether, soluble in In ether and certain organic solvents. Its English chemical name: (1β)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman(S,S)-(+)-Tetrandrin. Early experiments have proved that tetrandrine has antihypertensive, coronary expansion, anticancer and antibacterial effects. Recent studies have shown that tetrandrine is a calcium channel blocker. Zhang Honglian introduced the anti-myocardial ischemia, anti-arrhythmia, antihypertensive, and anti-allergic effects of tetrandrine and its mechanism of acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K8/63A61K8/49A61Q19/00A61P37/08A61K31/4748
Inventor 管书旺
Owner SHANGHAI ZIBANG BIO PHARMA CO LTD
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