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Application of human albumin in preparing drug for treating subarachnoid hemorrhage

A human albumin, subarachnoid technology, applied in drug combination, peptide/protein composition, pharmaceutical formulation, etc., can solve the problems of rupture of aneurysm, increase of intracranial pressure, increase of cardiac load, etc.

Inactive Publication Date: 2014-07-09
刘新峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on this pharmacological effect, on the one hand, human serum albumin helps to maintain blood volume and cerebral perfusion pressure after SAH, but it may also increase cardiac load, increase intracranial pressure, and induce aneurysm rupture or pulmonary edema.
There is no previous research evidence for its true efficacy

Method used

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  • Application of human albumin in preparing drug for treating subarachnoid hemorrhage
  • Application of human albumin in preparing drug for treating subarachnoid hemorrhage
  • Application of human albumin in preparing drug for treating subarachnoid hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1 Materials and methods

[0022] 1.1 Reagents and instruments

[0023] 20% human serum albumin (German Biotest), 10% chloral hydrate, Evans blue (Sigma-aldrich), formamide, water bath, oven, microplate reader (Biotech), etc.

[0024] 1.2 Experimental animals

[0025] Adult healthy male Sprague-Dawley (SD) rats, 300-350g, were provided by the Animal Experiment Center of Nanjing General Hospital of Nanjing Military Region, and were reared in a single cage for 3 days before operation to avoid the influence of non-specific factors, and were kept at room temperature 20±2°C. 12-hour light / 12-hour dark environment, free to eat and drink.

[0026] 1.3 Experimental method

[0027] 1.3.1 Animal grouping

[0028] SD rats were randomly divided into sham operation group, SAH group, low-dose albumin group (0.63g / kg), high-dose albumin group (1.25g / kg).

[0029] (1) Sham operation group: the thread plug was inserted into the brain, but the blood vessel was not punctured;

[0030...

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Abstract

The invention belongs to the technical field of novel uses of drugs and in particular relates to an application of human albumin in preparing a drug for treating subarachnoid hemorrhage. Confirmed by experiments, the human albumin with a certain concentration can be used for improving early brain injuries after the subarachnoid hemorrhage, including relieving brain edema, lowering the death and the apoptosis of nerve cells and improving the damage to blood brain barrier, thus protecting brain tissues. The application can be used for preparing the drug for treating the subarachnoid hemorrhage, particularly to the drug for treating nerve injury after the subarachnoid hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of human serum albumin in the preparation of medicines for treating subarachnoid hemorrhage. Background technique [0002] Subarachnoid hemorrhage (SAH) refers to a stroke in which blood flows into the subarachnoid space after the rupture of blood vessels at the base of the brain or on the surface of the brain, causing corresponding clinical symptoms. It is also called primary subarachnoid hemorrhage. SAH accounts for about 5%-10% of all strokes, with an annual incidence of about 6-20 / 100,000 people. [0003] Common causes of SAH include congenital aneurysm, cerebrovascular malformation, abnormal vascular network disease in the base of the brain (moyamoya disease), dissecting aneurysm, vasculitis, and arteriosclerosis in hypertension. Blood enters the subarachnoid space, rapidly disseminates through the cerebrospinal fluid that surrounds...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/38A61P9/10A61P25/00
Inventor 叶瑞东谢怡刘新峰
Owner 刘新峰
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