Synthesis and screening of sulfonate antibacterial anti-mite agent and compounding of novel anti-mite agent

The technology of an anti-mite agent and chlorobenzene sulfonate is applied in the field of research and development and preparation of high-efficiency new odor antibacterial and anti-mite agents, which can solve problems such as meaninglessness and lack of odor and acaricidal performance.

Inactive Publication Date: 2014-07-09
温州市颐康家居卫生用品有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] To improve the anti-mite function of mattresses, this requires that the antibacterial and anti-mite agents we have developed should not only have high contact killing performance against mites, but also have considerable odor killing performance; Odor mite killing performance, which is meaningless for mattress anti mite

Method used

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  • Synthesis and screening of sulfonate antibacterial anti-mite agent and compounding of novel anti-mite agent
  • Synthesis and screening of sulfonate antibacterial anti-mite agent and compounding of novel anti-mite agent
  • Synthesis and screening of sulfonate antibacterial anti-mite agent and compounding of novel anti-mite agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The synthetic method of embodiment 1 quinoline sulfonate (a-1) environmental protection acaricide:

[0025]

[0026] In an ice bath, using triethylamine as a catalyst, add p-chloro (or fluoro) benzenesulfonyl chloride dropwise to the dichloromethane solvent of 8-hydroxyquinoline or 5-chloro-8-hydroxyquinoline (1:1 molar ratio) After mixing and stirring uniformly for 1 h, the reaction was stirred at room temperature 25° C. for 24 h. After the reaction is completed, concentrate, crystallize, and wash repeatedly with deionized water to remove unreacted by-products of benzenesulfonyl chloride. The yield was 85%.

[0027] Characterization of the product:

[0028] (1) Characterization of 8-hydroxyquinoline p-chlorosulfonate

[0029] Infrared characterization of 8-hydroxyquinoline p-chlorosulfonate. 3046.9cm -1 The broad absorption peak at is the stretching vibration peak of C-H on the benzene ring, 1590.9cm -1 、1492.6cm -1 、1469.4em -1 The strong absorption peak at...

Embodiment 2

[0042] Embodiment 2 2,3-phenol sulfonate (a-3) environmental protection acaricide synthetic method:

[0043]

[0044] In an ice bath, use triethylamine as a catalyst, add p-chloro (or fluoro) benzenesulfonyl chloride dropwise to the dichloromethane solvent of 2,3-dichlorophenol, mix, stir evenly for 1 hour, and then stir at room temperature 25°C Reaction 24h. After the reaction is completed, concentrate, crystallize, and wash repeatedly with deionized water to remove unreacted by-products of benzenesulfonyl chloride. The yield was 85%.

[0045] Characterization of the product:

[0046] (1) Characterization of 2,-dichlorophenol p-fluorophenolsulfonate

[0047] The product is analyzed by mass spectrometry. In the mass spectrogram, 319.9 (m / z) is the molecular ion peak of 2,3-dichlorophenol p-fluorophenol sulfonate, and 160.0 (m / z) is [2,3-dichlorophenol Phenoxy-H + ] ion fragment peak, 159.0 (m / z) is the p-fluorobenzenesulfonyl ion fragment peak, and 95.0 (m / z) is the p-...

Embodiment 3

[0053] Embodiment 3 2,5-phenol sulfonate (a-4) environmental protection acaricide synthetic method:

[0054]

[0055] In an ice bath, using triethylamine as a catalyst, add p-chloro (or fluoro) benzenesulfonyl chloride dropwise to the dichloromethane solvent of 2,-dichlorophenol, mix, stir evenly for 1 hour, and then stir the reaction at room temperature 25°C 24h. After the reaction is completed, concentrate, crystallize, and wash repeatedly with deionized water to remove unreacted by-products of benzenesulfonyl chloride. The yield was 91%.

[0056] Characterization of the product:

[0057] (1) Characterization of 2,5-dichlorophenol p-chlorophenol sulfonate

[0058] The product is analyzed by mass spectrometry. In the mass spectrogram, 335.9 (m / z) is the molecular ion peak of 2,5-dichlorophenol p-chlorophenol sulfonate, and 175.0 (m / z) is [p-chlorobenzenesulfonyl] Ion fragmentation peak, 159.0 (m / z) is 2,5-dichlorophenoxy ion fragmentation peak, 111.0 (m / z) is p-chlorob...

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Abstract

The invention discloses a novel sulfonate antibacterial anti-mite agent and a research method for an efficient complexation of the agent. The novel sulfonate antibacterial anti-mite agent comprises quinolin-8-yl 4-chlorobenzenesulfonate and 2,3-dichlorophenyl 4-fluorobenzenesulfonate; and an efficient compound anti-mite agent preferably comprises quinolin-8-yl 4-chlorobenzenesulfonate and 2,3-dichlorophenyl 4-fluorobenzenesulfonate with a ratio of 3:2. The novel anti-mite agent is a sulfonate antibacterial anti-mite agent possessing the advantages of being wide in antibacterial spectrum, efficient, high in durability, safe and the like, and is applicable to substantially reduce levels of dermatophagoides pteronyssinus and dermatophagoides farina allergens of household interior ornaments, carpets, sofas and mattresses. The sulfonate antibacterial anti-mite agent is characterized by possessing both extremely strong mite contact killing capability and extremely strong smell mite killing capability.

Description

technical field [0001] The invention relates to the technical field of chemical industry, in particular to the research and development and preparation technology of a new type of odor-resistant antibacterial and anti-mite agent with high efficiency. Background technique [0002] Dozens—thousands—of mites are found in every gram of air in the indoor air we live in, with 20-40 species. The lifespan of the mite is about 3 months, and the female mite lays about 50 eggs in a lifetime, which increases geometrically, and develops from one female mite to 13 million eggs after 60 days. Among the indoor mites, dust mites are the most common. In the home, the most mites are distributed in carpets, followed by quilts, and then mattresses, pillows, floors, sofas, etc. Thousands of dust mites live in beds, pillows, bedding, decorative fabrics and carpets. They will produce a strong allergen, causing allergic diseases such as allergic asthma, allergic rhinitis and allergic dermatitis. C...

Claims

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Application Information

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IPC IPC(8): C07D215/32C07C309/73C07C303/28A01N43/42A01N41/04A01P7/02A01P1/00
CPCC07D215/32A01N41/04A01N43/42C07C303/28C07C309/73A01N2300/00
Inventor 林海杨宇翔李永霞施浩威
Owner 温州市颐康家居卫生用品有限责任公司
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