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Disposable Bioreactor

A technology of bioreactor and reactor, which is applied in the direction of bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, biochemical instrument, etc. The effect of mass efficiency

Active Publication Date: 2017-03-22
ZHENGZHOU VIRIGE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a disposable bioreactor to solve the problem of low mixing and mass transfer efficiency in existing shaker-driven non-intervention mixing existing shaker-driven bioreactors

Method used

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Examples

Experimental program
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Embodiment Construction

[0062] Example 1 of a disposable bioreactor, such as Figure 1-5 As shown, the disposable bioreactor includes a reactor cavity and a connecting pipe 11, and the reactor cavity is made of non-toxic and harmless plastic material, which can meet the requirement of one-time use, from figure 1 , 2 It can be seen from the figure that the reactor chamber is formed by the fusion of two chamber walls. The two chamber walls are arranged one above the other. The upper one is the upper chamber wall 12, the lower one is the lower chamber wall 13, and the upper one is the lower chamber wall 13. 1. The fusion of the lower cavity wall forms a joint edge 14, which can support and pull the reactor cavity through the joint edge 14 when needed; the connecting pipe 11 is located on the upper cavity wall 12 and is an integral structure with the upper cavity wall 12 . In this embodiment, the upper and lower cavity walls are all solid support cavity walls, that is, the cavity walls that can maintai...

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Abstract

The invention relates to the technical field of bioreactors, in particular to a disposable bioreactor. The disposable bioreactor includes a reactor cavity and a communication pipe, the communication pipe is located at the top of the reactor cavity, the reactor cavity is formed by fusion connection or adhesive connection of two or more cavity walls and has an intersection part and at least one hollow arm part which is converging and communicating with the communication pipe through the intersection part, and the end of the hollow arm part is closed. The invention utilizes a rocking shaker, a plane gyratory shaker and a three-dimensional gyratory shaker to drive the liquid in the reactor cavity to flow along its long axis, thereby generating waves and turbulent mixing, and generating eddy current mixing and augmentation with the existing shaking table-driven reactor. Compared with the method of atmospheric liquid exchange surface area, the mixing and mass transfer efficiency are greatly improved.

Description

technical field [0001] The invention relates to the technical field of bioreactors, in particular to a disposable bioreactor. Background technique [0002] Shaker-driven non-intervention mixing bioreactors include small culture tubes, spinner flasks, Erlenmeyer flasks, inverted conical bottom flasks, flat conical bottom flasks and flat conical bottom tanks, and stirring bioreactors of different sizes driven by impellers , is currently the most widely used bioreactor for fermentation and cell suspension culture. The common feature of shaker-driven non-interventional mixed bioreactors is that the opening is located at one end of the reactor and is coaxial with the long axis of the reactor cavity. Except for the rotating bottle, which is placed horizontally, the opening is at the upper end and the reaction is driven by rotation or gyration. It is realized by the vortex generated by the liquid in the vessel. However, the principle of increasing the liquid surface area to incre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/02C12M1/00
CPCC12M23/02C12M23/28C12M23/34C12M23/38C12M29/06C12M41/26C12M41/34
Inventor 韩志强童胜刘慧涛
Owner ZHENGZHOU VIRIGE BIOTECH
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