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Application of total schisandra lignans in preparation of medicaments or health-care products for treating cough

A technology of total lignans and schisandra, applied in the field of biomedicine

Active Publication Date: 2014-08-13
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, total lignans, as an important component of Schisandra chinensis, have not been reported in the literature on whether it has a cough-relieving effect

Method used

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  • Application of total schisandra lignans in preparation of medicaments or health-care products for treating cough
  • Application of total schisandra lignans in preparation of medicaments or health-care products for treating cough
  • Application of total schisandra lignans in preparation of medicaments or health-care products for treating cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Example 1: Pharmacological effects of total lignans from Schisandra chinensis on guinea pigs with increased cough sensitivity induced by cigarette smoke stimulation

[0031] 1.1 Smoking method: After the guinea pigs were adaptively reared for one week before the experiment, they were placed in a self-made cigarette poisoning box, and 10 cigarettes were lit each time in the smoking tank (cured tobacco type, tar content 12mg, smoke nicotine content 1.1 mg, the carbon monoxide content in the flue gas is 15 mg), the cigarette smoke is injected into the poisoning box through the three-way valve, and the timing starts from the end of the cigarette burning. Smoke for 20 minutes each time, smoke twice a day, and the interval between each second smoke is more than 6 hours, and smoke continuously for 14 days.

[0032] 1.2 Experiment:

[0033] Guinea pigs were completely randomly divided into normal group, model group, solvent control group (0.5% PEG400), codeine group, water extr...

Embodiment 2

[0054] After the guinea pigs rested for a week, carry out cough sensitivity screening: 0.8mol / L citric acid atomization stimulation for 1min, stop atomization, continue to observe for 5min, record the number of coughs within 6min from the start of atomization, the guinea pigs with more than 10 times and less than 50 times are Qualified guinea pigs.

[0055] The qualified guinea pigs that are screened are completely randomly divided into normal group, solvent control group (0.5% PEG400), codeine group, water extract high-dose group (dose 500mg / kg guinea pig / day, drug concentration 50mg / mL), total wood Lignin high dose group (dose 500mg / kg guinea pig / day, drug concentration 50mg / mL), total lignans middle dose group (dose 250mg / kg guinea pig / day, drug concentration 25mg / mL), total lignans low dose group (dose 125mg / kg guinea pig / day, drug concentration 12.5mg / mL), schisandrin high-dose group (dose 500mg / kg guinea pig / day, drug concentration 50mg / mL), schisandrin high-dose group (...

Embodiment 3

[0067] After the guinea pigs rested for a week, carry out cough sensitivity screening: 0.8mol / L citric acid atomization stimulation for 1min, stop atomization, continue to observe for 5min, record the number of coughs within 6min from the start of atomization, the guinea pigs with more than 10 times and less than 50 times are Qualified guinea pigs.

[0068]After the qualified guinea pigs were fed normally for 3 days, they were randomly divided into 4 groups with 30 guinea pigs in each group. The first large group was randomly divided into 3 groups, 10 in each group, and were directly stimulated by citric acid cough: 0.8mol / L citric acid atomized stimulation for 1 minute, stopped the atomization, continued to observe for 5 minutes, and recorded the cough within 6 minutes from the beginning of atomization. Number of coughs. The second largest group was randomly divided into 3 groups: normal group, codeine group (30mg / kg, oral administration), Schisandra total lignans group (250...

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Abstract

The invention relates to a new application of total schisandra lignans in preparation of medicaments or health-care products for treating cough, and in particular relates to a new application in preparation of medicaments or health-care products for preventing cough, relieving cough and eliminating airway inflammation. Experiments show that the total schisandra lignans can be used for significantly reducing the cough frequency of cavies suffering from increased cough sensitivity caused by cigarette smoke stimulus and acute cough caused by citric acid smog stimulus, prolonging the cough latency and significantly reducing the airway inflammation of the cavies suffering from increased cough sensitivity caused by cigarette smoke stimulus, so that the total schisandra lignans can be used for preparing the medicaments for preventing cough, relieving cough and eliminating airway inflammation.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the use of total lignans from Schisandra chinensis in the preparation of medicines or health care products for treating cough, especially the use of total lignans from Schisandra fruit in the preparation of medicines or health care products for antitussive, cough relief and airway inflammation new uses in products. Background technique [0002] Cough is the most common symptom in medical clinics, and it is seen in a variety of respiratory and non-respiratory diseases. Coughing itself is a defense mechanism to clear excess secretions in the airways and prevent aspiration of foreign matter into the airways. However, long-lasting cough seriously affects the quality of life of patients and causes a serious psychological burden on patients, and also significantly increases personal and public health expenditures. [0003] According to the course of the disease, cough includes acute cough (&...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K36/79A61P11/14
CPCA61K9/19A61K31/09A61K36/57A61K36/79
Inventor 赖克方钟山甘振勇刘晓东聂怡初钟南山
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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