Unlock instant, AI-driven research and patent intelligence for your innovation.

Treatment and prevention of diseases related to oxidative stress

A technology for oxidative stress and disease conditions, applied in metabolic diseases, blood diseases, extracellular fluid diseases, etc.

Inactive Publication Date: 2014-08-20
UNIV OF PECS
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no indication of the fact that -Tyr itself as an active agent would be suitable for the prevention of hormone resistant diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Treatment and prevention of diseases related to oxidative stress
  • Treatment and prevention of diseases related to oxidative stress
  • Treatment and prevention of diseases related to oxidative stress

Examples

Experimental program
Comparison scheme
Effect test

example

[0167] Materials and methods

[0168] basic material

[0169] Insulin, epinephrine, p-, m-, o-tyrosine, and Mg2SO4 were purchased from Sigma-Aldrich (Sigma-Aldrich, St. Louis, MO 63178, USA) . NaCl, KCl, KH2PO4, NaHCO3, glucose and CaCl2*2H2O were purchased from Merck (Merck KGaA, 64271 Darmstadt, Germany).

[0170] cell culture

[0171] Primary cultures of mouse embryonic fibroblasts (3T3-L1) were purchased from ATCC (Manassas, USA). Supplemented with 10% fetal bovine serum (Gibco (Gibco), CAT number: 16170-078), 100U / ml penicillin and 0.1mg / ml streptomycin (Gibco, CAT number: 15070-063) and 398nM Dulbecco's modified Eagle medium (Dulbecco's modified Eagle medium, DMEM, Invitrogen, CAT number: 41966-029; Sigma-Aldrich CAT number: D6046) of p-, m- or o-Tyr Early passage of 3T3-L1 fibroblasts. DMEM contains 25 mM or 5 mM glucose (depending on the experiment), L-glutamine and pyruvate. Cells were grown in a humidified incubator at 37°C and 5% CO2. The differentiation med...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The present invention relates to the field of treatment and prevention of conditions related to oxidative stress and hormone resistance. Preferably, insulin resistance, and erythropoietin resistance and acetyl-choline resistance are in the focus. The invention also relates to the field of use of amino acids, in particular p-L-Tyrosine and a precursor thereof as a medicament or composition or formulation in the prevention or treatment of said conditions.

Description

technical field [0001] The present invention relates to the field of treatment and prevention of conditions due to oxidative stress and hormone resistance. Preferably, insulin resistance, erythropoietin resistance and acetylcholine resistance are the focus. The invention also relates to the field of the use of amino acids, in particular p-L-tyrosine and its precursors, as medicaments or compositions or formulations for the prevention or treatment of said conditions. Background technique [0002] Adipose tissue is an active endocrine and paracrine organ that not only affects body weight homeostasis but also plays an important role in inflammation, which induces oxidative stress (OS), leading to e.g. insulin resistance and diabetes (Iozzo 2009, Houstis 2006). OS causes an imbalance between reactive oxygen species (ROS) and antioxidant defenses. ROS especially involve superoxide anion radicals (·O 2 - ), hydrogen peroxide (H 2 o 2 ) and hydroxyl radicals (·OH). • OH can...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P5/50A61P5/00A61P7/06A61P9/10A61P13/12A61P35/00A61P3/10A61P3/04
CPCA61K31/192A61K31/198A23L1/3051A23L33/175A61P3/04A61P3/10A61P5/00A61P5/50A61P7/06A61P9/10A61P13/12A61P35/00
Inventor 伊什特万·维特曼盖尔格·阿提拉·莫尔纳朱迪特·莫哈斯切赫伊什特万·安德拉什·兹雅托
Owner UNIV OF PECS