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A traditional Chinese medicine composition for treating chronic heart failure and its preparation method and application

A chronic heart failure and composition technology, applied in the field of traditional Chinese medicine composition and its preparation for the treatment of chronic heart failure, can solve the problems of failing to effectively reduce the mortality rate of CHF and fundamentally improving the quality of life of patients

Active Publication Date: 2017-08-25
YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Traditional drugs for the treatment of CHF mainly include diuretics, ACEI (angiotensin-converting enzyme inhibitors), vasodilators, cardiotonic agents, myocardial nutrients, calcium channel blockers, etc., but they have not fundamentally improved the quality of life of patients , also failed to effectively reduce the mortality rate of CHF, and there are many problems in clinical application

Method used

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  • A traditional Chinese medicine composition for treating chronic heart failure and its preparation method and application
  • A traditional Chinese medicine composition for treating chronic heart failure and its preparation method and application
  • A traditional Chinese medicine composition for treating chronic heart failure and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Example 1 Granules

[0034] Weigh the following raw materials: Astragalus 1500g, Codonopsis 750g, Tinglizi 750g, Guizhi 450g, Safflower 450g, Antler 100g.

[0035] Add 10 times the amount of water to soak for 6 hours in the above six medicinal materials, add 10 times the amount of water to soak Astragalus, Codonopsis, Safflower, and Guizhi for 30 minutes, combine the medicinal liquids for decoction, boil for 45 minutes, filter, and collect the filtrate , add 8 times the amount of water to the filter residue, decoct, boil for 30 minutes, filter, combine the filtrates, concentrate under reduced pressure to a density of 1.02-1.10 (70±3°C), high-speed centrifugation (16000r / min), weigh, and then add to No. 5 Sieve, mix the sterilized antler powder and appropriate amount of auxiliary materials evenly, pass through an 80-mesh sieve, filter, and spray the filtrate to dry at an inlet air temperature of 185±2°C and an outlet air temperature of 90±2°C, spray dry and granulate int...

Embodiment 2

[0037] Example 2 Granules

[0038] Weigh the following raw materials: astragalus 1000g, Codonopsis 500g, Tinglizi 750g, cassia twig 300g, safflower 300g, antler 50g.

[0039] Add 10 times the amount of water to soak for 6 hours in the above six medicinal materials, add 10 times the amount of water to soak Astragalus, Codonopsis, Safflower, and Guizhi for 30 minutes, combine the medicinal liquids for decoction, boil for 45 minutes, filter, and collect the filtrate , add 8 times the amount of water to the filter residue, decoct, boil for 30 minutes, filter, combine the filtrates, concentrate under reduced pressure to a density of 1.02-1.10 (70±3°C), high-speed centrifugation (8000r / min), weigh, and then add to No. 5 Sieve, mix the sterilized antler powder and appropriate amount of auxiliary materials evenly, pass through an 80-mesh sieve, filter, and spray the filtrate to dry at an inlet air temperature of 185±2°C and an outlet air temperature of 90±2°C, spray dry and granulate ...

Embodiment 3

[0040] Example 3 Granules

[0041] The traditional Chinese medicine raw materials in the following weight proportions are used: 2000g of astragalus, 1000g of Codonopsis pilosula, 1000g of Tinglizi, 450g of cassia twig, 600g of safflower, and 100g of antler (referring to the daily crude drug dose). Prepared by:

[0042] Add 10 times the amount of water to soak for 6 hours in the above six medicinal materials, add 10 times the amount of water to soak Astragalus, Codonopsis, Safflower, and Guizhi for 30 minutes, combine the medicinal liquids for decoction, boil for 45 minutes, filter, and collect the filtrate , add 8 times the amount of water to the filter residue, decoct, boil for 30 minutes, filter, combine the filtrates, concentrate under reduced pressure to a density of 1.02-1.10 (70±3°C), high-speed centrifugation (8000r / min), weigh, and then add to No. 5 Sieve, mix the sterilized antler powder and appropriate amount of auxiliary materials evenly, pass through an 80-mesh si...

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Abstract

The invention belongs to the field of traditional Chinese medicine pharmaceutics, and relates to a traditional Chinese medicine composition for treating chronic heart failure as well as a preparation method and application thereof. The traditional Chinese medicine composition mainly comprises the following raw material medicaments in parts by weight: 20-40 parts of astragalus, 10-20 parts of pilose asiabell root, 6-9 parts of cassia twig, 15-20 parts of descurainia seed, 1-2 parts of deer-horn and 6-12 parts of safflower; the raw materials are matched with auxiliary materials to be prepared into granular preparations for treating the stage B of chronic heart failure. Experiments show that the traditional Chinese medicine preparation disclosed by the invention can be used for improving the symptoms and signs of patients suffering chronic heart failure, preventing the further development of chronic heart failure, and relatively well treating and preventing chronic heart failure, is convenient for taking, controllable in quality and good in effects, and can not cause side or toxic effects after long-term medication.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic heart failure, a preparation method and application thereof. Background technique [0002] Chronic heart failure (CHF) is a clinical syndrome in the severe or terminal stage of various cardiac diseases. The common causes of CHF are coronary heart disease, hypertension, diabetes and various cardiomyopathy, among which heart failure caused by coronary heart disease is the first. [0003] The morbidity and mortality of CHF remain high, which is closely related to the clinical course of CHF. The 2007 Chinese Guidelines for the Diagnosis and Treatment of Chronic Heart Failure and the 2005 American Heart Failure Guidelines both pointed out that CHF is a progressive disease. Once it starts, even if there is no new myocardial damage, it is still in a stable clinical stage and can still continue on its...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61K36/9068A61P9/04A61K35/32A61K35/62
Inventor 周华戎靖枫薛金贵袁秀荣瞿惠燕王成荣赵国英黄牧华
Owner YANGTZE RIVER PHARMA GRP JIA NGSU LONGFENGTANG TRADITIONAL CHINESE MEDICINE CO LTD
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