Application of toluylene compounds in preparation of anticomplement medicaments

A technology of stilbenes and compounds, applied in the direction of active ingredients of hydroxyl compounds, drug combinations, antipyretics, etc.
CN104055754AInactive Publication Date: 2014-09-24FUDAN UNIV
0 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2014-09-24
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the field of pharmacy, and relates to a new application of toluylene compounds in preparation of anticomplement medicaments. According to the invention, toluylene compounds are prepared from ethyl acetate extraction positions of roots of polygonum cuspidatum Sieb. et Zucc., and are confirmed to have strong inhibition effect on the classical pathway and the alternative pathway of the complement system by in-vitro anticomplement activity evaluation tests. The CH50 of the compounds for the inhibition effect on the classical pathway of the complement system is 110+ / - 12, 250+ / -20 [mu]g / ml, and the AP50 for the inhibition effect on the alternative pathway of the complement system is 800+ / -25, 440+ / -15 [mu]g / ml. The compounds can be used for preparation of anticomplement medicaments.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy and relates to a new application of stilbene compounds in the preparation of anti-complement drugs. Background technique

[0002] The complement system is an important immune defense system in the body and participates in most pathophysiological processes in the body. The complement system is a double-edged sword. Its normal activation plays an important role in resisting the invasion of foreign microorganisms and maintaining the balance of the body. However, excessive activation of the complement system can cause systemic lupus erythematosus, rheumatoid arthritis, and acute respiratory distress syndrome. symptoms and many other diseases. At present, there is no ideal drug for the treatment of such diseases, so there is an urgent need for a new type of complement inhibitor with high efficiency, low toxicity and specificity in clinical practice. It is low cost and safe to rese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More