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A kind of yew wall breaking preparation

A yew and preparation technology, applied in the field of traditional Chinese medicine, can solve the problems of loss of active ingredients, easy moisture absorption, increase in powder specific surface area, etc., and achieve good disintegration and stability, easy disintegration and dispersion, and granulation process simple effect

Active Publication Date: 2018-08-21
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional decocting method is easy to destroy its heat-sensitive components. On the other hand, the decoction of the active ingredients is not complete, resulting in the loss of the active ingredients, and directly decocting the yew will bring out the toxicity of the yew at the same time.
The preparation of yew into yew ultrafine powder is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of the specific surface area of ​​the powder, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • A kind of yew wall breaking preparation
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  • A kind of yew wall breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take the yew medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and then superfinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 45 μm, add ethanol-water solution (the mass fraction of ethanol is 30 %) Wet process soft material, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 10 mesh sieve, select extrusion speed 50r / min, extrusion force 1MPa to make wet Granules, wet granules are placed in a hot air circulating oven, set the drying temperature to 75°C, and dried for 2.5 hours until dry, and the yew wall-broken preparation is obtained after the granules are sized and sieved.

[0040]

[0041] Note: The full score is 10.

Embodiment 2

[0043] Take the yew medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and then superfinely pulverize it into a powder with 90% of the particle size less than or equal to 45 μm in the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 40 %) soft material by wet method, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 70r / min, and the extrusion force is 0.7MPa. Wet granules, the wet granules are transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, and dried for 0.75h to dryness.

[0044]

[0045] Note: The full score is 10.

Embodiment 3

[0047] Take the yew medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and then superfinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 45 μm, add ethanol-water solution (the mass fraction of ethanol is 60 %) soft material by wet method, the ratio of solution to superfine powder is 0.8:1 (by weight), after mixing, pre-installed 20-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa. Wet granules, the wet granules are transferred to a hot air circulation oven, set the drying temperature to 75°C, and dried for 2.5 hours until dry.

[0048]

[0049] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken Chinese yew preparation. A preparation method for the wall-broken Chinese yew preparation comprises the following steps: crushing Chinese yew into wall-broken powder; then carrying out ethanol-water wet granulation by controlling the mass of an ethanol solution and the wall-broken powder; carrying out extrusion forming at a certain rotating speed; and then carrying out drying. The preparation method has a high granulation rate; and the prepared wall-broken Chinese yew preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a yew wall-breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. However, the current ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/13A61K9/16A61P35/00A61J3/00
Inventor 成金乐陈勇军梁学良钱锦花黄艺蓉
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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