Compound polyninylpyrrolidone sterilizing agent and preparation method thereof

A disinfectant and vitality technology, applied in the direction of inorganic non-active ingredients, skin diseases, antibacterial drugs, etc., can solve the problems of not being able to promote wound healing, easy sublimation of iodine, and irritation

Inactive Publication Date: 2014-10-08
武汉品瑞医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Povidone-iodine is in a complex state under stable conditions, which overcomes the shortcomings of iodine tincture, such as easy sublimation, irritation, and yell

Method used

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  • Compound polyninylpyrrolidone sterilizing agent and preparation method thereof
  • Compound polyninylpyrrolidone sterilizing agent and preparation method thereof
  • Compound polyninylpyrrolidone sterilizing agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 The formula of a kind of compound active iodine disinfectant is as table 1:

[0036]

[0037] a. Mix 20g povidone-iodine PVP-I with 5g potassium iodate KIO 3 Dissolve in 947.5g of purified water; b. Add 2g of sodium nitrilotriacetate and stir evenly; c. Add 5g of potassium iodide KI and stir evenly; d. Add 0.5g of vitamin A to 20g of ethanol to dissolve; e. In the ketone-iodine solution c, stir evenly; f. adjust the pH to 7.5 with 5% sodium hydroxide solution to obtain the compound active iodine disinfectant.

Embodiment 2

[0038] Embodiment 2 The formula of a kind of compound active iodine disinfectant is as table 2:

[0039]

[0040] a. Mix 55g povidone-iodine PVP-I with 5g potassium iodate KIO 3 Dissolve in 871.5g of purified water; b. Add 10g of sodium edetate and stir evenly; c. Add 7.5g of potassium iodide KI and stir evenly; d. Add 1g of vitamin A to 50g of isopropanol to dissolve; e. Add povidone-iodine solution c, stir evenly; f. adjust the pH to 7.5 with 5% sodium hydroxide solution to obtain the compound active iodine disinfectant.

Embodiment 3

[0041] Embodiment 3 The formula of a kind of compound active iodine disinfectant is as table 3:

[0042]

[0043] a. Mix 100g povidone-iodine PVP-I with 7.5g potassium iodate KIO 3 Dissolve in 757.5g of purified water; b. Add 20g of sodium diethylenetriamine pentaacetate and stir evenly; c. Add 10g of potassium iodide KI and stir evenly; d. Add 5g of vitamin A to 100g of dimethyl sulfoxide to dissolve; e. d. Add povidone-iodine solution c and stir evenly; f. adjust the pH to 7.5 with 5% sodium hydroxide solution to obtain the compound active iodine disinfectant.

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Abstract

The invention relates to a compound polyninylpyrrolidone sterilizing agent and a preparation method thereof. The sterilizing agent comprises the following components (by wt%): 2.0-10.0% of povidone-iodine PVP-I, 0.05-0.5% of vitamin A, 0.5-1.0% of potassium iodate KIO3, 0.5-1.0% of potassium iodide KI, 0.2-2.0% of chelating agent, 1.0-10.0% of organic solvent, a proper amount of pH modifier, and the balance of water. The preparation method comprises the steps of a. dissolving the povidone-iodine PVP-I and potassium iodate KIO3 into a proper amount of purified water; b. adding the chelating agent and mixing uniformly; c. adding the potassium iodide KI and mixing uniformly; d. adding the vitamin A into the organic solvent and dissolving; e. adding a vitamin A solution d into a povidone-iodine solution c, and mixing uniformly; and f. adjusting the pH to be 7.0-8.0 with the pH modifier, so as to obtain the compound polyninylpyrrolidone sterilizing agent. The compound polyninylpyrrolidone sterilizing agent has stable property and strong sterilizing effect, and can promote wound healing.

Description

technical field [0001] The invention relates to a compound active iodine disinfectant. Background technique [0002] Povidone-iodine (Polyvinyl pyrrolidone-Iodine, PVP-I) is a new type of iodine-containing sterilizing preparation. PVP-I is a complex formed by polyvinylpyrrolidone (PVP) and iodine, containing 9~12% of available iodine. PVP is stable in nature and generally does not cause incompatibility with other drugs. After forming a complex with iodine, the iodine element is combined with the inner side of the PVP helical structure, which greatly improves the solubility of iodine. for continuous disinfection. Povidone-iodine is in a complex state under stable conditions, which overcomes the shortcomings of iodine in iodine tincture, such as easy sublimation, irritation, and yellow dye that needs to be deiodized with ethanol. Povidone-iodine, although effective in inhibiting bacteria on undamaged skin surfaces, did not promote wound healing. There is evidence that iodi...

Claims

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Application Information

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IPC IPC(8): A61K31/79A61K47/20A61K47/02A61K47/18A61P31/04A61P17/02A61K31/07
Inventor 周利娟颜锵鲁至诚
Owner 武汉品瑞医学科技有限公司
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