Cornus officinalis total saponins obtained by response surface method optimized ultrasonic-microwave synergetic extraction and method for extracting total saponins from cornus officinalis

A response surface method, the technology of Cornus officinalis, applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems that cannot meet the extraction requirements of Cornus officinalis, can not be fully utilized, and the extraction is not thorough, etc., to achieve the regression equation High precision, shortened extraction time, and high raw material utilization

Active Publication Date: 2014-10-22
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the leaching method and the reflux method are time-consuming and low in extraction rate; the ultrasonic method and the microwave method have many impurities and incomplete extraction and other shortcomings, and because there is no uniform standard for the limitation of extraction conditions, Cornus officinalis can not be fully utilized, and the extraction rate is low, which cannot meet the requirements. Extraction Requirements of Total Saponins from Cornus officinalis in Industrial Production

Method used

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  • Cornus officinalis total saponins obtained by response surface method optimized ultrasonic-microwave synergetic extraction and method for extracting total saponins from cornus officinalis
  • Cornus officinalis total saponins obtained by response surface method optimized ultrasonic-microwave synergetic extraction and method for extracting total saponins from cornus officinalis
  • Cornus officinalis total saponins obtained by response surface method optimized ultrasonic-microwave synergetic extraction and method for extracting total saponins from cornus officinalis

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example 1

[0038] The method for optimizing the ultrasonic-microwave synergistic extraction of total saponins from Cornus officinalis by response surface methodology of the present invention comprises the following steps:

[0039] (1) Material processing: Soak the fresh and ripe fruit of Cornus officinalis in boiling water for several minutes, rinse and cool it under running water, and remove the core; dry and pulverize the remaining pulp, and pass through a 40-mesh sieve to obtain medicinal material powder of Cornus officinalis;

[0040] (2) Ultrasonic-microwave synergistic extraction: Weigh a certain amount of cornus officinalis medicinal material powder, put it in a reaction vessel, add an ethanol solution with a volume fraction of 70% according to the ratio of solid to liquid ratio of 1:21 and seal it, and connect the condensing device , extracted at a temperature of 70°C, a microwave power of 417W, and an ultrasonic power of 369W for 5 minutes to obtain an extract; Redissolve to obt...

example 2

[0044] The method for optimizing the ultrasonic-microwave synergistic extraction of total saponins from Cornus officinalis by response surface methodology of the present invention comprises the following steps:

[0045] (1) Material processing: Soak the fresh and ripe fruit of Cornus officinalis in boiling water for several minutes, rinse and cool it under running water, and remove the core; dry and pulverize the remaining pulp, and pass through a 40-mesh sieve to obtain medicinal material powder of Cornus officinalis;

[0046](2) Ultrasonic-microwave collaborative extraction: Weigh a certain amount of cornus officinalis medicinal material powder, put it in a reaction container, add an ethanol solution with a volume fraction of 70% according to the ratio of solid to liquid 1:10 and seal it, and connect the condensing device , at a temperature of 70°C, a microwave power of 600W, and an ultrasonic power of 500W for 6 minutes to obtain an extract; Redissolve to obtain total sapon...

example 3

[0050] The method for optimizing the ultrasonic-microwave synergistic extraction of total saponins from Cornus officinalis by response surface methodology of the present invention comprises the following steps:

[0051] (1) Material processing: Soak the fresh and ripe fruit of Cornus officinalis in boiling water for several minutes, rinse and cool it under running water, and remove the core; dry and pulverize the remaining pulp, and pass through a 40-mesh sieve to obtain medicinal material powder of Cornus officinalis;

[0052] (2) Ultrasonic-microwave synergistic extraction: Weigh a certain amount of cornus officinalis medicinal material powder, place it in a reaction container, add an ethanol solution with a volume fraction of 70% according to the ratio of solid to liquid ratio of 1:15 and seal it, and connect the condensing device , extracted at a temperature of 70°C, a microwave power of 200W, and an ultrasonic power of 420W for 9 minutes to obtain an extract; Redissolve t...

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Abstract

The invention provides a method for extracting cornus officinalis total saponins by response surface method optimized ultrasonic-microwave synergetic extraction. The method comprises the following steps: (1) treating materials to obtain cornus officinalis powder; (2) performing ultrasonic-microwave synergetic extraction to obtain a total saponin sample solution; and (3) purifying by macroporous resin, concentrating and drying eluent to obtain powdered cornus officinalis total saponins. The cornus officinalis total saponins can be prepared by the extracting method. According to the method, the cavatition effect of ultrasonic wave and the high-performance infrared heating effect of microwave are combined, so that a sample can be quickly, effectively and reliably treated, the extraction time is shortened, the extraction efficiency is improved, the material-liquid ratio, the microwave power, the ultrasonic power and the extraction time can be respectively limited while the extract structure is guaranteed, and the extraction rate of the cornus officinalis total saponins is 13.96mg / g and is increased by up to 20 percent. The method has high raw material utilization rate, is effective and saves time, can be used for greatly saving cost, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of extraction of total saponins, and relates to total saponins of Cornus officinalis and a method for optimizing ultrasonic-microwave synergistic extraction by response surface method. Background technique [0002] Cornus officinalis is a perennial plant of the Cornus officinalis family. Its medicinal part is the dried pulp after the ripe fruit has been pitted. It is one of the three most valuable woody medicinal materials in the world. effect. Cornus officinalis pulp contains iridoids, saponins, tannins, polysaccharides, vitamins, amino acids and minerals and other effective ingredients. Modern pharmacological studies have shown that saponins are one of the important bioactive components of Cornus officinalis, which have the functions of regulating immunity, lowering blood sugar, anti-arrhythmia and inhibiting the proliferation and division of cell lines. [0003] At present, the extraction methods of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P37/02A61P3/10A61P9/06A61K131/00
Inventor 康杰芳王红菊杨宁白嫄王韶君王喆之
Owner SHAANXI NORMAL UNIV
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