A traditional Chinese medicine mixture assisting treatment of gastroesophageal reflux disease, a preparing method thereof and applications of the mixture

A gastroesophageal reflux and adjuvant treatment technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of large side effects and long treatment cycle of proton pump inhibitors, so as to relieve side effects and shorten the time of treatment. Effect of treatment cycle

Inactive Publication Date: 2014-10-29
张英剑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The primary purpose of the present invention is to provide a Chinese medicine mixture for assisting proton pump inhibitors (esomeprazole sodium) in the treatment of gastroesophageal reflux disease, aiming at solving the long treatment cycle of proton pump inhibitors (esomeprazole sodium) , long-term use of side effects

Method used

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  • A traditional Chinese medicine mixture assisting treatment of gastroesophageal reflux disease, a preparing method thereof and applications of the mixture
  • A traditional Chinese medicine mixture assisting treatment of gastroesophageal reflux disease, a preparing method thereof and applications of the mixture
  • A traditional Chinese medicine mixture assisting treatment of gastroesophageal reflux disease, a preparing method thereof and applications of the mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) 60g plum root bark, 20g Yuanhu, 100g parts by mass of sword bean and 100g loquat leaves are mixed and ground into coarse material, and the coarse material is soaked in 280ml of 95% alcohol for 2 to 3 days, and then The coarse material is soaked in 290ml mature vinegar for 5-7 days and filtered to obtain the soaking filtrate and medicinal residues.

[0027] (2) Boil the medicinal residues obtained in the step (1) twice with water, each time for 1 to 2 hours, collect the medicinal liquid, simmer the medicinal liquid to concentrate to obtain a concentrated medicinal liquid, pour the concentrated medicinal liquid into 150ml of ethanol, stir and mix evenly, filter after standing for 24 hours, and obtain 150ml of purified medicinal liquid after removing impurities; the water is boiled to make medicinal residues.

[0028] (3) the soaking filtrate that described step (1) is obtained is mixed with the purified medicinal liquid that obtains in step (2), and this mixed solutio...

Embodiment 2

[0030] (1) 120g plum root bark, 5g Yuanhu, 150g sword bean, and 50g loquat leaves are mixed and ground into a coarse material, and the coarse material is soaked in 290ml of 95% alcohol for 2 to 3 days, and then the coarse material Soak in 290ml mature vinegar for 5-7 days and filter to obtain soaking filtrate and medicinal residues.

[0031] (2) Boil the medicinal residues obtained in the step (1) twice with water, each time for 1 to 2 hours, collect the medicinal liquid, simmer the medicinal liquid to concentrate to obtain a concentrated medicinal liquid, pour the concentrated medicinal liquid into 160ml of ethanol, stir and mix evenly, filter after standing for 24 hours, and obtain 190ml of purified medicinal liquid after removing impurities; the water is boiled twice with water for 1 to 2 hours each time.

[0032] (3) the soaking filtrate that described step (1) is obtained is mixed with the purified medicinal liquid that obtains in step (2), and this mixed solution is simm...

Embodiment 3

[0034] (1) 120g plum root bark, 5g Yuanhu, 150g sword bean, 50g loquat leaves and 60g Atractylodes macrocephala are mixed and ground into coarse material, and the coarse material is soaked in 290ml of 95% alcohol for 2 to 3 days, and then Soak the crude material in 290ml mature vinegar for 5-7 days and filter to obtain soaking filtrate and medicinal residues.

[0035] (2) Boil the medicinal residues obtained in the step (1) twice with water, each time for 1 to 2 hours, collect the medicinal liquid, simmer the medicinal liquid to concentrate to obtain a concentrated medicinal liquid, pour the concentrated medicinal liquid into 160ml of ethanol, stir and mix evenly, filter after standing for 24 hours, and obtain 190ml of purified medicinal liquid after removing impurities; the water is boiled twice with water for 1 to 2 hours each time.

[0036] (3) the soaking filtrate that described step (1) is obtained is mixed with the purified medicinal liquid that obtains in step (2), and ...

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Abstract

A traditional Chinese medicine mixture assisting treatment of gastroesophageal reflux disease, a preparing method thereof and applications of the mixture are provided. The traditional Chinese medicine mixture is prepared by steps of: mixing Japanese plum root-bark, corydalis tuber, sword bean and loquat leaf, grinding into a coarse material, dipping the coarse material in alcohol having a concentration of 95%, dipping the coarse material in old vinegar, filtering to obtain the dipping filtrate and medicine dregs, collecting a medicine liquid after the medicine dregs are decocted with water, concentrating the medicine liquid with soft fire to obtain a concentrated medicine liquid, adding the concentrated medicine liquid into ethanol, stirring, allowing the mixture of the concentrated medicine liquid and the ethanol to stand, filtering to remove impurities so as to obtain a purified medicine liquid, mixing the dipping filtrate and the purified medicine liquid, and concentrating the liquid mixture with soft fire. The traditional Chinese medicine mixture can be used as an assisting medicine for esomeprazole sodium and used for treatment of the gastroesophageal reflux disease, can effectively shorten the treating period of the gastroesophageal reflux disease, and effectively relieve side effects brought by long-term use of the esomeprazole sodium to patients.

Description

technical field [0001] The invention belongs to the technical field of auxiliary medicines, and in particular relates to a traditional Chinese medicine mixture for treating gastroesophageal reflux disease with an auxiliary proton pump inhibitor (esomeprazole sodium) and its preparation method and application. Background technique [0002] Proton pump inhibitors (PPIs) are the drug of choice for the treatment of acid-related diseases such as peptic ulcer and gastroesophageal reflux disease. Currently, there are five commonly used PPIs in clinical practice: omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. As the first PPI drug, omeprazole has been unanimously recognized for its efficacy in the treatment of acid-related diseases. Esomeprazole, trade name Nexium, is the S-optical isomer of omeprazole and the world's first isomer proton pump inhibitor (PPI), which specifically inhibits the proton pump of gastric parietal cells Reduce gastric acid secretion...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P1/04A61K31/4439
Inventor 张英剑郭虹彭霞王萍吕姝焱潘新娟
Owner 张英剑
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