Vertical logistics based solvent crystallization method

Abstract

The invention relates to the pharmaceutical field, especially to production of bulk drugs by a solvent crystallization method and to a sterile logistics method, particularly a vertical logistics based solvent crystallization method. According to the traditional solvent crystallization method, solid-liquid separation is carried out on a material liquid after crystal growing, and a corresponding material flow system is designed to transfer the separated solid by the action of gravity. With the method provided by the invention, environmental exposure caused pollution problems can be avoided during material transfer, and the prepared bulk drugs have a high sterile level. In addition, the logistics system with gravity as the main driving force has the characteristics of high transport efficiency and low cost.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the production of raw materials by solvent crystallization, and also to an aseptic logistics method. Background technique [0002] The production of sterile raw materials by the solvent crystallization method usually goes through processes such as dissolution, sterile filtration, crystallization, solid-liquid separation, drying, crushing, and packaging. The traditional method adopts plane operation. Since the material obtained in the process of solid-liquid separation is powder, it will inevitably be exposed to the air during the transfer process. Although 100-level laminar flow protection is used during the exposure process, due to the Manual operation is still required for remaining. In fact, exposed materials cannot be transferred in a dynamic A-level clean environment, and the level of sterility assurance is low. Therefore, in the production process of sterile raw materials, how to p...

AI Technical Summary

Problems solved by technology

The traditional method adopts plane operation. Since the material obtained in the process of solid-liquid separation is powder, it will inevitably be exposed to the air during the transfer process. Although 100-level laminar flow protection is used during the exposure process, due to the Manual operation is still required for remaining. In fact, exposed materials cannot be transferred in a dynamic A-level clean environment, and the level of sterility assurance is low.

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