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Polymer test cartridge mixer for cell lysis

A technology for testing boxes, polymer layers, applied in the direction of fluid mixers, containers for laboratory use, mixers, etc.

Active Publication Date: 2014-10-29
HONEYWELL INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Merely adding reagents to blood samples may not be sufficient, resulting in inhomogeneous measured samples due to incomplete lysis of cells by lysing agents

Method used

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  • Polymer test cartridge mixer for cell lysis
  • Polymer test cartridge mixer for cell lysis
  • Polymer test cartridge mixer for cell lysis

Examples

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Embodiment Construction

[0010] In the following description, reference is made to the accompanying drawings, which form a part hereof, and in which are shown by way of example specific embodiments that may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that other embodiments may be utilized and structural, logical and other modifications may be made without departing from the scope of the invention. and electrical changes. Accordingly, the following description of exemplary embodiments is not in a limiting sense, and the scope of the present invention is defined by the appended claims.

[0011] A plurality of fluidic structures formed in the polymer layer of the test cartridge are used to mix the reagents with the red blood cells. The mixing that occurs within these structures aids in the lysis of red blood cells to release the heme into the solution to be measured. The unique shape of the c...

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Abstract

A multiple polymer layer test cartridge (100, 300) includes an input (110, 310) to receive a sample containing cells, multiple lysing channel structures (130, 140, 330, 340, 350, 360) on alternate layers of the multiple layer test cartridge coupled to each other to pass the sample in sequence between the lysing channel structures, and a test chamber (370) to receive the sample from the multiple lysing channel structures.

Description

Background technique [0001] Hemoglobin measurement in automated tests employs a reagent to aid in the lysis of red blood cells to release hemoglobin from a blood sample into solution. Merely adding reagents to blood samples may not be sufficient, resulting in inhomogeneous measured samples due to incomplete lysis of cells by the lysing agent. Contents of the invention [0002] A multi-layer test cartridge comprising: an input for receiving a sample comprising cells; a plurality of lysis channel structures on alternating layers of the multi-layer test cartridge, the alternating layers being coupled to each other to sequentially transporting the sample between the lysis channel structures; and a test chamber for receiving the sample from the plurality of lysis channel structures. [0003] In another embodiment, a polymer-based test cartridge includes: an input for receiving a sample comprising red blood cells and having reagents to mix with the sample; a plurality of sequent...

Claims

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Application Information

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IPC IPC(8): G01N21/01G01N1/38G01N21/31G01N35/10
CPCB01L3/502746B01L2300/0816G01N33/726B01L2300/0883B01L2200/10B01L2300/0887B01L2300/0874B01F13/0059B01F25/4321B01F33/30
Inventor P.黄P.亨宁E.帕莱马
Owner HONEYWELL INT INC
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