Respiratory tract drug delivery device and method

Abstract

The invention discloses a respiratory tract drug delivery device and method. According to the device and the method, drugs or particles containing the drugs are charged with charges with certain polarity, the human body is charged with charges with the same polarity as that of the drug particles until the drug particles reach the preset depositing portion along with airflow, and instantly, the polarity of the charges with which the human body is charged is changed, so that the polarity of the charges of the human body is opposite to that of the charges of the drug particles, and the drug particles fast deposit on the surface of the respiratory tract of the preset portion under the effect of electric field force; respiratory tract drug delivery is carried out many times, a current meter or a voltage meter is adopted for monitoring the amounts of electric signals generated by depositing and discharging of the drug particles on the surface of the respiratory tract each time, the total electric signal amount of drug delivery of many times is obtained by accumulating the signal amounts, and the total amount of the drugs depositing on the part of the designated respiratory tract can be calculated out according to the numerical value proportional relation between the discharging signal amounts and the drug depositing amounts obtained through experimental measurement. According to the device and the method, many factors influencing the drug absorption efficiency are overcome, and the adverse reaction is reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a device and method for drug delivery through the respiratory tract. Background technique [0002] In recent years, with the in-depth analysis of lung function and diseases such as rhinitis, influenza, bronchitis, asthma, emphysema, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer, it has been recognized that respiratory drug delivery (including oral , nasal cavity administration and pulmonary administration, which can be collectively referred to as inhalation administration) is the most simple and effective route of administration for the treatment of the above-mentioned diseases. Compared with other routes of administration, pulmonary administration has the advantages of large absorption surface area, abundant blood flow at the absorption site, avoiding the first-pass effect of the liver, low enzyme activity, thin epithelial barrier and...

AI Technical Summary

Problems solved by technology

[0020] The purpose of the embodiments of the present invention is to provide a device and method for drug administration in the respiratory tract, aiming to provide an effective and practical technology that allows the dose of drug administration in the respiratory tract to be controllable, the location of drug deposition and absorption can be selected, and the lungs of the drug The amount deposited in the area is close to the labeled amount of the drug, which solves the problems of many factors affecting drug absorption efficiency, complex operation, and high incidence of adverse reactions

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