Controlled-release lincomycin granules

A technology of lincomycin and sustained-release granules, which can be applied in the directions of bulk delivery, digestive system, antibacterial drugs, etc., can solve the problems of reducing the frequency of taking medicine, inconvenient taking, slowing down the absorption rate, etc.

Active Publication Date: 2014-12-03
邳州舜邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of inconvenient taking and low bioavailability of the existing lincomycin preparations, the present invention invented lincomycin inclusion compound slow-release granules, which can reduce the number of times of taking medicine, slow down the absorption rate, prolong the biological half-life, and make the blood medicine The concentration is controlled within the effective blood concentration range, thereby reducing side effects and improving patient compliance

Method used

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  • Controlled-release lincomycin granules
  • Controlled-release lincomycin granules
  • Controlled-release lincomycin granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 prescription

[0032] Lincomycin inclusion complex: lincomycin:γ-cyclodextrin is 2:3.5

[0033] Lincomycin inclusion complex

50 copies

lactose

190 copies

Magnesium stearate

4 parts

sodium saccharin

4 parts

hypromellose

70 copies

Glyceryl monostearate

30 copies

PVC

85 copies

[0034] Preparation:

[0035] 1. Prepare lincomycin inclusion compound according to the following method:

[0036] (1) In water or aqueous ethanol medium, react lincomycin with γ-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and separate the clathrate from the mixture; or

[0037] (2) in solid form, reacting lincomycin with γ-cyclodextrin; or

[0038] (3) Lincomycin reacts with γ-cyclodextrin for high-energy grinding.

[0039] 2. Grind the lincomycin inclusion compound through a 100-mesh sieve, and crush the rest of the excipi...

Embodiment 2

[0041] Fully grind lincomycin and γ-cyclodextrin described in Example 1 in 50% ethanol until a uniform paste is formed, and after vacuum drying, a white powder is obtained, which is more soluble in water than unincluded lincomycin Mycin was increased by 17 times.

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Abstract

The invention relates to controlled-release lincomycin granules. Firstly, tamoxifen citrate is prepared into a clathrate compound and then the clathrate compound is prepared into the controlled-release granules.

Description

technical field [0001] The present application relates to a sustained-release granule, specifically, a lincomycin inclusion compound sustained-release granule. Background technique [0002] Lincomycin, the English name is Lincomycin. It acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the elongation of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Chemical name: 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-6,8-dideoxy-D-erythro-α-D- Galactopyranoside hydrochloride monohydrate. Lincomycin is a white crystalline powder; it has a slight or special odor; it tastes bitter. Lincomycin is easily soluble in water or methanol and slightly soluble in ethanol. Lincomycin acts on the 50S subunit of the ribosome of susceptible bacteria to prevent the elongation of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Lincomycin is generally a bacteriostatic agent, but at high concent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7056A61P31/04A61P11/00A61P19/08A61P19/02A61P17/00A61P1/16
Inventor 黄祥彬李志征周祎谢姗瑾
Owner 邳州舜邦生物科技有限公司
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