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Application of Mexico artemisin in preparing antitumor drugs

An anti-tumor drug, artemisinin technology, applied in the field of medicine

Inactive Publication Date: 2014-12-10
NANJING BIAOKE BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through literature search, no Mexican artemisinin has been used in the preparation of anti-tumor drugs in China

Method used

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  • Application of Mexico artemisin in preparing antitumor drugs
  • Application of Mexico artemisin in preparing antitumor drugs
  • Application of Mexico artemisin in preparing antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of Mexican artemisinin

[0051] Take 500g of the coarse powder of the aerial part of Artemisia Chrysanthemum, put it in an extraction kettle, add methanol as an entrainer at a solid-to-liquid volume ratio of 5:2, and feed in liquid CO2 at a pressure of 22MPa and a temperature of 38°C, with a CO2 flow rate of 4.5ml / g crude drug / min, extract for 120min, analyze at a pressure of 7MPa and a temperature of 32°C, collect the extract, add 15g of diatomaceous earth to stir for decolorization, filter to obtain a decolorization solution, concentrate to a relative density of 1.12, and put on a neutral alumina column (column pressure is 6bar, column diameter-to-height ratio is 1:8), eluted and purified with petroleum ether-ethyl acetate 3:14, and the crude product of Mexican artemisinin is obtained; the volume ratio is 19:38:45 methanol-acetonitrile-water Mobile phase, the crude product is dissolved in the mobile phase, injected into the preparative high-performance li...

Embodiment 2

[0053] Tablet: 40g of Mexican artemisinin, 135g of starch, 25g of chenodeoxycholate, granulated and compressed into 1000 tablets. Dosage: Adults take 1 tablet at a time, 2 times a day.

Embodiment 3

[0055] Capsules: Mexican artemisinin 40g, starch 135g, chitosan 25g, mix well, and make 1000 capsules. Dosage: Adults take 1 capsule at a time, 2 times a day.

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Abstract

The invention discloses application of Mexico artemisin in preparing antitumor drugs. The antitumor effect of the Mexico artemisin is observed through in vitro inhibition assay on in vitro tumor cells and the observation results show that Mexico artemisin has a certain inhibition effect on lung cancer and colon cancer, has an obvious antitumor activity and hardly causes toxic or side effects. The Mexico artemisin and pharmaceutically acceptable accessories can be prepared into antitumor drugs, and the antitumor drugs can be in any dosage form of injection, capsule, tablet, granules, pills, mixture and oral liquid.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of Mexican artemisinin in the preparation of antitumor drugs. Background technique [0002] Mexican artemisinin is a sesquiterpene lactone component isolated from the aerial part of Artemisia chrysanthemum, and its molecular formula is C 15 h 20 o 4 , molecular weight is 264.32, molecular structure formula: [0003] [0004] Pharmacological studies have shown that Mexican artemisinin has cytotoxic activity, IC for human small cell lung cancer column and human colon cancer line 50 15.2μM and 18.5μM (the control substance Cisplatin is 1.0μM and 3.0μM). [0005] Through literature search, no Mexican artemisinin has been used in the preparation of antitumor drugs in China. Contents of the invention [0006] In order to meet the clinical needs, expand the variety of drugs, and treat cancer better, Mexican artemisinin was used to prepare anti-tumor drugs. [0007] Techni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P35/00
Inventor 张金芳杨存
Owner NANJING BIAOKE BIO TECH