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A system to detect Alzheimer's risk

A technology for risk detection devices, applied in measurement devices, biological testing, material inspection products, etc., to solve problems such as incompatibility, discomfort, and danger

Active Publication Date: 2016-08-17
MAGQU
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the process of getting a cerebrospinal fluid sample is relatively dangerous and uncomfortable
Therefore, it is not suitable for screening methods required for large-scale investigations or multiple sample collections required for long-term observation of disease development or efficacy

Method used

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  • A system to detect Alzheimer's risk
  • A system to detect Alzheimer's risk
  • A system to detect Alzheimer's risk

Examples

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Embodiment Construction

[0068] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. Unless otherwise specified, the reagents, equipment and methods used in the present invention are commercially available reagents, equipment and routinely used methods in this technical field.

[0069] The spirit of the present invention is to use the concentration product of two Alzheimer's disease biomarkers tau protein and Aβ-42 protein to identify the risk of Alzheimer's disease. Based on this spirit, the present invention includes but is not limited to the above and the following descriptions. The implementation is shown in the following example.

[0070] 61 patients with different degrees of Alzheimer's dementia from mild (CDR0.5), moderate (CDR1) to severe (CDR3) assessed by Clinical Dementia Rating Scale (CDR) and Plasma from 66 healthy controls was collected for superconducting immunomagnetic subtraction analysis of amyloid a...

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Abstract

The invention provides a system for detecting the risk of alzheimer's diseases. The system comprises a detection device, a computing device, and an identifying device, wherein the detection device is used for detecting magnetic decrement signals generated by two alzheimer's disease biomarkers in individual biological specimens, wherein the two alzheimer's disease biomarkers are tau protein and Abeta-42 protein; the computing device is used for converting the magnetic decrement signals of the two alzheimer's disease biomarkers into the concentrations of the two alzheimer's disease biomarkers; and the identifying device is used for detecting the risk of the alzheimer's diseases according to the product of the values of concentrations of the two alzheimer's disease biomarkers.

Description

technical field [0001] The present invention relates to a method of analyzing the concentration product of Alzheimer's disease biomarker Aβ-42 protein and tau protein by immunomagnetic subtraction to determine the risk of Alzheimer's disease. Background technique [0002] Due to the rapid aging of the global population, neurodegenerative diseases have become a serious problem today. Dementia is the most prevalent neurodegenerative disease. The prevalence of people over the age of 60 is 5%-7% in most regions of the world, and it is estimated that nearly 35,600,000 people worldwide were living with dementia in 2010. The World Health Organization has called on governments, policymakers and other stakeholders to recognize the impact of dementia as a growing threat and to deploy the necessary resources to prepare health and social care systems to respond The looming threat of dementia. [0003] Alzheimer's disease accounts for 50%-70% of all elderly people with dementia. Neur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/54326G01N33/54346G01N33/6896
Inventor 杨谢乐
Owner MAGQU
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