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Composition, and external preparation for the skin or functional food each containing said composition

A technology for functional foods and external preparations for skin, which can be used in medical preparations containing active ingredients, preparations for skin care, food preparation, etc., and can solve problems such as unfinished interpretation

Active Publication Date: 2014-12-24
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, although the physiological activity possessed by the carotenoid, pterostilbene has been studied, the interpretation throughout its entire aspect has not yet been carried out.

Method used

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  • Composition, and external preparation for the skin or functional food each containing said composition
  • Composition, and external preparation for the skin or functional food each containing said composition
  • Composition, and external preparation for the skin or functional food each containing said composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3、 comparative example 1～9

[0140] Each composition was prepared by mixing and stirring using a magnetic stirrer (AS ONE company) so that the composition described in Table 2 might be obtained.

[0141] For each composition, the improvement property of fine lines was evaluated.

[0142] 10 males were used as a group to conduct the test, and the composition of the comparative example was applied to the left corner of the eye twice a day, morning and evening, and the composition of the example was applied to the right corner of the eye.

[0143] After continuous daily application for 1 month, compare the photos before the experiment with the photos after the experiment, and evaluate according to the improvement scores shown in Table 3. At the same time, the symptoms of pigmentation of the skin shown in Table 4 were investigated by questionnaire and evaluated. The results are shown in Table 5.

[0144]

[0145] [table 3]

[0146] score

state of fine lines

4

high degree of improve...

Embodiment 4

[0154] NFκB is thought to be involved in incipient skin aging. Therefore, the rate of intranuclear transfer inhibition of NFκB based on carotenoids and pterostilbene was investigated.

[0155] Human normal fibroblasts (HDF cells, warehouse Shiki Textile Co., Ltd.) for three generations. Make subcultured HDF cells adhere to 1 million cells / 25cm 2 container to keep it serum starved for a day. Then, HDF cells were washed with phosphate-buffered saline (PBS).

[0156] The cells were irradiated with UVB (20 mJ) from directly above, and then replaced with a medium in which 0.1% of FBS was added to D-MEM containing carotenoids and pterostilbene shown in Tables 6 and 7.

[0157] After 6 hours of displacement, the nuclei were extracted by NucBuster (Novagen), and transferred by Western Blot (WB) method (primary antibody: NF-κB p65 rabbit monoclonal antibody (Cat. #1546-1), EPITOMICS company) The amount of nuclear transfer of NF-κB to the nucleus was quantified.

[0158] The resul...

Embodiment 5

[0165] Using the compositions obtained in Examples 1 to 3, drinks 1 to 3 respectively corresponding to the compositions of Examples 1 to 3 were prepared by the following composition and production method.

[0166]

[0167] (1) The composition of embodiment 1, 2 or 3

[0168] 20g

[0169] (2) Fructose glucose liquid sugar

[0170] 120g

[0171] (3) Vitamin C (L-ascorbic acid)

[0172] 10g

[0173] (4) Citric acid

[0174] 10g

[0175] (5) Citrus Spice

[0176] 3g

[0177] (6) water

[0178] 837g

[0179] total

[0180] 1000g

[0181]

[0182] The components of (2) to (6) were mixed and dissolved using a 2L stainless steel container. Then, the component of (1) was added, and it mixed at 500 rpm using the magnetic stirrer (AS ONE company), and the drink liquid was prepared.

[0183] This was filled in a bottle, and it heat-sterilized at 85 degreeC for 10 minutes. It was cooled to room temperature to obtain ...

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Abstract

The present invention provides: a composition which has an effect of preventing or improving skin conditions including the formation of small wrinkles and the sagging of the skin; and an external preparation for the skin or a functional food, each of which contains the composition. The present invention relates to: a composition comprising carotenoid and pterostilbene; and an external preparation for the skin or a functional food, each of which contains the composition.

Description

technical field [0001] The present invention relates to a composition, an external preparation for skin containing the composition, or a functional food. Background technique [0002] Various factors, such as aging and ultraviolet rays, are known as causes of changes accompanying skin aging such as fine lines and sagging of the skin. [0003] In order to prevent or improve these skin symptoms, various active ingredients were searched and researched together. For example, ascorbic acid and derivatives thereof are known to be effective in improving skin symptoms such as fine lines and sagging skin (Patent Document 1). [0004] On the other hand, carotenoids are known to have various physiological activities such as antioxidative action. For example, Non-Patent Document 1 discloses a relationship between cancer and carotenoids. [0005] In addition, it is known that stilbene compounds have the effect of suppressing keratinization of epidermal cells and maintaining proliferat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A23L1/30A61K8/35A61K31/01A61K31/015A61K31/05A61K31/122A61P17/00A61Q19/00A61Q19/08A23L33/155
CPCA61K8/35A61Q19/08A61K31/015A61K31/05A61K31/122A61K9/0014A61K8/31A61K8/347A61Q19/02A23L5/44A23L33/10A23L33/105A23L33/155A61P17/00A61P17/16A61P43/00A61K2300/00
Inventor 村口太一提艾利智子
Owner FUJIFILM CORP
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