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Chitosan gel dropping pill for gynaecologic bacteriostasis and preparation method thereof

A technology of sugar gel dripping pills and chitosan, which is applied in the direction of medical preparations containing active ingredients, pill delivery, antibacterial drugs, etc., can solve the problem of gel adhesion and therapeutic effect, biocompatibility changes Poor, reduced stability and other issues, to achieve the effect of improving bioavailability, long-lasting effect, and high drug concentration

Active Publication Date: 2015-01-07
武汉品瑞医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The chitosan gel preparation disclosed above is based on chitosan, and other drugs are added, such as chlorhexidine acetate, Chinese medicine extracts or nano silver, etc., resulting in poor biocompatibility.
In addition, the gel preparation is susceptible to seasonal or temperature changes, which will reduce its stability, cause a lot of loss and odor, and directly affect the adhesion and therapeutic effect of the gel.

Method used

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  • Chitosan gel dropping pill for gynaecologic bacteriostasis and preparation method thereof
  • Chitosan gel dropping pill for gynaecologic bacteriostasis and preparation method thereof
  • Chitosan gel dropping pill for gynaecologic bacteriostasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of formula for the chitosan gel dripping pill of gynecological antibacterial is as table 1:

[0025]

[0026] Dissolve sodium chloride in purified water to prepare a sodium chloride solution, then add high-molecular-weight chitosan and low-molecular-weight chitosan into the sodium chloride solution to make a uniform chitosan-sodium chloride mixture suspension, then add gellan gum, and add an appropriate amount of acetic acid to adjust the pH to 5.5-6.5 to obtain a composite chitosan gel. Add the composite chitosan gel into the molten mixture of molten polyethylene glycol 6000 and stearic acid, stir and mix evenly, add it to the dropping pill machine and drop it into pills, wipe off the cooling liquid on the surface of the dropping pills, and dry , to get chitosan gel dripping pills.

[0027]

Embodiment 2

[0029] A kind of formula for the chitosan gel dripping pill of gynecological antibacterial is as table 2:

[0030]

[0031] Dissolve sodium chloride in purified water to prepare a sodium chloride solution, then add high-molecular-weight chitosan and low-molecular-weight chitosan into the sodium chloride solution to make a uniform chitosan-sodium chloride mixture suspension, then add carrageenan, and add appropriate amount of acetic acid to adjust the pH to 5.5-6.5 to obtain a composite chitosan gel. Add the composite chitosan gel into the mixed melt of polyethylene glycol 4000 and poloxamer, stir and mix evenly, add it into the dropping pill machine and drop it into pills, wipe off the cooling liquid on the surface of the dropping pills, and dry to obtain Chitosan gel drop pills.

Embodiment 3

[0033] A kind of formula for the chitosan gel dripping pill of gynecological antibacterial is as table 3:

[0034]

[0035] Dissolve sodium chloride in purified water to prepare a sodium chloride solution, then add high-molecular-weight chitosan and low-molecular-weight chitosan into the sodium chloride solution to make a uniform chitosan-sodium chloride mixture suspension, then add gelatin, and add an appropriate amount of acetic acid to adjust the pH to 5.5-6.5 to obtain a composite chitosan gel. Add the composite chitosan gel into the mixed melt of polyoxyethylene monostearate and poloxamer, stir and mix well, add it to the dropping pill machine and drop it into pills, wipe off the cooling liquid on the surface of the dropping pills, Dry to get chitosan gel dripping pills.

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Abstract

The invention relates to a chitosan gel dropping pill for gynaecologic bacteriostasis and a preparation method thereof. The gel dropping pill comprises the following constituents: compound chitosan with different molecular weights and deacetylation degrees, gelatinizer, acidifier, sodium chloride, purified water and dropping pill matrix. The method comprises the steps of mixing the compound chitosan and aqueous solution of sodium chloride with certain concentration, so as to form suspension, then feeding a proper amount of gelatinizer to the suspension, adjusting the pH value of the suspension through the acidifier, feeding compound chitosan gel obtained into matrix melt, uniformly mixing the compound chitosan gel and the matrix melt, and feeding the compound chitosan gel and the matrix melt into a pill dropping machine to prepare dropping pills, so as to obtain the chitosan gel dropping pill. The chitosan gel dropping pill is good in roundness, rapid in drug dissolution and high in bioavailability, the antibacterial ability of the chitosan gel dropping pill for gram-positive bacteria and gram-negative bacteria reaches greater than 99 percent, and the chitosan gel dropping pill is applied to the curing of monilial vaginitis, bacterial vaginitis, trichomonas vaginitis or cervicitis in gynecology, has good curative effect, high safety and good biocompatibility. The invention also relates to a preparation method and the medical application of the chitosan gel dropping pill.

Description

technical field [0001] The invention relates to a chitosan gel dripping pill for gynecological antibacterial and a preparation method thereof. Background technique [0002] Chitosan (Chitosan), widely present in the crustaceans of shrimps, crabs and insects, the chemical name is poly(1,4)-2-amino-2-deoxy-β-D-glucose, is the It is a natural biopolymer obtained after partial or complete deacetylation of ketones. It is the only macromolecular alkaline polysaccharide existing in nature. It has the characteristics of good biocompatibility, no toxic side effects, easy absorption, and broad-spectrum antibacterial properties. , has been widely developed and applied in the food industry, chemical industry, synthesis of medical polymer materials and other fields. Studies have shown that chitosan with low molecular weight has better antibacterial effect on Gram-positive bacteria, while for Gram-negative bacteria, the antibacterial ability of chitosan increases with the increase of mol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/722A61K47/02A61P15/00A61P31/04
CPCY02A50/30
Inventor 周利娟颜锵鲁至诚
Owner 武汉品瑞医学科技有限公司
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