Method for rapidly determining content of index components of Qingkailing oral solution

A technology for Qingkailing oral liquid and Ling oral liquid is applied in the field of rapid determination of the content of index components in Qingkailing oral liquid, which can solve the problems of low efficiency, high cost, long time consumption and the like

Inactive Publication Date: 2015-01-21
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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Problems solved by technology

[0004] The purpose of the present invention is to overcome the disadvantages and deficiencies of the prior art such as long time-consuming, low efficiency and high cost, and provide a method for rapid determination of the index component content of Qingkailing Oral Liquid, which has the advantages of convenience, quickness, low cost and high efficiency.

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  • Method for rapidly determining content of index components of Qingkailing oral solution
  • Method for rapidly determining content of index components of Qingkailing oral solution
  • Method for rapidly determining content of index components of Qingkailing oral solution

Examples

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Embodiment 1

[0058] Example 1 Determination of Qingkailing Oral Liquid

[0059] (1) Acquisition of calibration set and its original spectral data

[0060] Collect samples from the samples of Qingkailing oral liquid to form a sample set, and use a near-infrared spectrometer to collect the original spectral data of the calibration set;

[0061] For samples of Qingkailing oral liquid, a total of 69 samples were collected from 69 batches, 50 of which were used as calibration sets, and the remaining 19 were used as prediction sets;

[0062] The original spectral data of the calibration set was collected by a near-infrared spectrometer: at room temperature (15-30 ° C), using Antaris Ⅱ FT-NIR Analyzer (Thermo Fisher Scientific Corporation, the United States, light source: tungsten halogen lamp, detector: InGaAs detection device, where the resolution is 8cm -1 , the number of scans is 32 times, and the scanning spectrum range is 10000~4 000cm -1 , with an optical path of 2mm) for dat...

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Abstract

The invention relates to a method for rapidly determining content of index components of a Qingkailing oral solution. The method comprises the following specific operation steps: (1) collecting a correction set and collecting original spectrum data; (2) determining the content of the index components of the Qingkailing oral solution; (3) establishing and checking a correction model; and (4) determining a new sample of the Qingkailing oral solution. The detection precision of the established model is close to that of a standard method and the detection precision of the content of the index components is remarkably improved; compared with an existing method, the determination time is greatly shortened and the determination of each sample commonly can be finished within one minute; the method can be used as a rapid quality control method which has extremely good application prospect; by adopting the method, the problems of traditional determination of the Qingkailing oral solution that the consumed time is long, the efficiency is low and the like are solved; and meanwhile, powerful technical guarantees are provided for the quality improvement of varieties of the Qingkailing oral solution and the like.

Description

technical field [0001] The invention belongs to the technical field of quality detection of liquid preparations of traditional Chinese medicines, and in particular relates to a method for rapidly measuring the content of index components of Qingkailing oral liquid. Background technique [0002] According to the definition of "Pharmacopoeia of the People's Republic of China" (2010 edition), traditional Chinese medicine oral liquid refers to "an oral liquid preparation prepared by extracting drinking pieces with water or other solvents by a suitable method." Qingkailing oral liquid is mainly composed of gardenia, Radix , honeysuckle, baicalin, cholic acid, hyodeoxycholic acid, mother of pearl and buffalo horn are extracted, purified and concentrated to a certain volume. Qingkailing oral liquid is an oral preparation, which has the advantages of small dosage, good taste, fast absorption, stable quality, convenient carrying and taking, and easy storage. Qingkailing Oral Liquid ...

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Application Information

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IPC IPC(8): G01N21/3577G01N21/359G01N30/02G01N31/16
Inventor 刘顺国黎洪肖雪刘明颖陈艳陈育娟黄江剑黄子健潘碧妍卢瑞芯
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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