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A preparation method of self-microemulsion particles containing astaxanthin and resveratrol

A technology of resveratrol and self-microemulsion, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, emulsion delivery, etc., can solve the problems of poor solubility and low bioavailability, and achieve improved solubility, High bioavailability, improving gastric dispersion and intestinal lipolysis

Active Publication Date: 2016-09-21
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The combined use of resveratrol and astaxanthin in a certain proportion has a synergistic effect in anti-oxidation and anti-aging applications. The solubility in the medium is not good, so its bioavailability is extremely low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The invention provides a method for preparing self-microemulsion particles containing astaxanthin and resveratrol. The preparation method includes the following steps:

[0023] (1) At 40°C, weigh 100g of Tween 80, 5g of caprylic acid / capric triglyceride and 1g of glycerin to fully mix to form a transparent and uniform blank self-microemulsion;

[0024] (2) At 40°C, weigh 3g of resveratrol and 0.1g of astaxanthin, add 12g of the blank self-microemulsion obtained in step (1), stir evenly to form a uniform transparent shape containing astaxanthin Self-microemulsion of vitamins and resveratrol;

[0025] (3) At 40°C, weigh 1g of hydroxypropyl methylcellulose, add 9g of the self-microemulsion containing astaxanthin and resveratrol obtained in step (2), and stir well to form Self-microemulsion containing astaxanthin and resveratrol in suspension;

[0026] (4) At 40°C, weigh 1g of microcrystalline cellulose, add 1g of the suspension-like self-microemulsion containing astaxant...

Embodiment 2

[0028] The invention provides a method for preparing self-microemulsion particles containing astaxanthin and resveratrol. The preparation method includes the following steps:

[0029] (1) At 50°C, weigh 100g of polyoxyethylene ether (35) castor oil, 15g of caprylic / capric triglyceride and 20g of PEG400 to fully mix to form a transparent and uniform blank self-microemulsion;

[0030] (2) At 50°C, weigh 3g of resveratrol and 1g of astaxanthin, add 30g of the blank self-microemulsion obtained in step (1), stir evenly to form a uniform transparent shape containing astaxanthin and Self-microemulsion of resveratrol;

[0031] (3) At 50°C, weigh 1g of hydroxypropyl methylcellulose, add 20g of the self-microemulsion containing astaxanthin and resveratrol obtained in step (2), stir well to form a suspension Self-microemulsion containing astaxanthin and resveratrol;

[0032] (4) At 50°C, weigh 1.5g of microcrystalline cellulose, add 1g of the suspension-like self-microemulsion containing...

Embodiment 3

[0034] The invention provides a method for preparing self-microemulsion particles containing astaxanthin and resveratrol. The preparation method includes the following steps:

[0035] (1) At 60°C, weigh 100g of polyethylene glycol-15-hydroxystearate, 30g of caprylic / capric triglyceride and 40g of 1,2-propanediol to form a transparent and uniform blank Self-microemulsion;

[0036] (2) At 60°C, weigh 3g of resveratrol and 3g of astaxanthin, add 57g of the blank self-microemulsion obtained in step (1), stir evenly to form a uniform transparent shape containing astaxanthin and astaxanthin Self-microemulsion of veratrol;

[0037] (3) At 60°C, weigh 1g of hydroxypropyl methylcellulose, add 49g of the self-microemulsion containing astaxanthin and resveratrol obtained in step (2), stir well to form a mixed Self-microemulsion containing astaxanthin and resveratrol in suspension;

[0038] (4) At 60°C, weigh 3g of microcrystalline cellulose, add 1g of the suspension-like self-microemu...

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Abstract

The invention discloses a preparation method of astaxanthin and resveratrol-containing self-microemulsion particles. The preparation method comprises the following steps: at a temperature of 40-60 DEG C, carrying out mixed dissolving on a surfactant, caprylic / capric triglyceride and a co-emulsifier, so that a blank self-microemulsion is obtained; adding resveratrol and astaxanthin into the blank self-microemulsion, and uniformly stirring, so that an astaxanthin and resveratrol-containing self-microemulsion is obtained; adding hydroxypropyl methylcellulose into the astaxanthin and resveratrol-containing self-microemulsion, and uniformly stirring, so that a mixed suspended astaxanthin and resveratrol-containing self-microemulsion is obtained; and finally, adding microcrystalline cellulose, so that the astaxanthin and resveratrol-containing self-microemulsion is changed into solid granular powder, namely, astaxanthin and resveratrol-containing self-microemulsion particles. Through the way, the preparation method disclosed by the invention is simple, and no special high-energy-consumption production equipment is required in the process of preparation; obtained products effectively increase the solubility of astaxanthin and resveratrol in water, and improve the influence of stomach scattering and intestinal lipolysis; and the effective bioavailability is high.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to a method for preparing self-microemulsion particles containing astaxanthin and resveratrol. Background technique [0002] In ancient times, "immortality" was the dream pursued by countless people. In modern times, there are still countless people who hope to "stay young forever". In the field of life sciences, everyone calls the exploration of this issue "research on anti-aging" , it can be seen that people's research on anti-aging has never stopped from ancient times to the present. This is an eternal topic. As we all know, only by knowing what it is, can we know why it is, and only by knowing the mechanism of aging can we better study anti-aging. [0003] Aging is a multifactorial and complex comprehensive physiological change process, and it is an inevitable stage in the growth process of individuals. Studies have shown that after the age of 30 in humans, various organs, ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K9/16A61K9/107A61P39/06A61K31/05
CPCA61K9/1075A61K9/1652A61K31/05A61K31/122A61K2300/00
Inventor 周华锋段明星徐之伟严泽民刘廷强孙春华
Owner KARLIE COSMETICS MFG CO LTD
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