A highly tropic bladder cancer-targeted tumor-killing adenovirus

A technology of adenovirus and bladder cancer, applied in the field of adenovirus for the treatment of bladder cancer, can solve the problems of lack of selective lysis of tumor cells, low replication ability of oncolytic adenovirus, difficulty in overcoming the immune system, etc., and achieve CAR receptor dependence Sexual problems, solving targeted problems, improving the effect of treatment
CN104328140BInactive Publication Date: 2018-06-05LANZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LANZHOU UNIVERSITY
Publication Date
2018-06-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to high tropism bladder cancer targeting tumor-killing adenovirus, and discloses modified replication defective adenovirus for treating bladder cancer. According to the present invention, the RGD sequence is integrated into the adenovirus cilium zone to change the adenovirus tropism so as to improve the tropism on the bladder cancer lowly expressing the adenovirus receptor and solve the problem of low infection capability of the adenovirus vector on the bladder cancer lowly expressing the adenovirus receptor; in the tropism-modified adenovirus, the bladder epithelium-specific UPII promoter is adopted to control the expression of the suicide gene TK so as to construct the selectively expressing adenovirus; and the CAR receptor dependence problem of the adenovirus in the prior art and the targeting problem of the adenovirus in the prior art can be solved, and the treatment effect can be increased.
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Description

technical field

[0001] The present invention relates to a modified virus that can be used to treat tumors, specifically, the present invention relates to an adenovirus that can be used to treat bladder cancer. Background technique

[0002] In my country, bladder cancer ranks first among urinary system tumors, causing serious losses in economic and social development, and the harm is very serious. Traditional radiotherapy and chemotherapy have disadvantages such as low anti-tumor ability, low killing index, and large side effects. The therapeutic effect is far from satisfactory. Therefore, it is very urgent to explore new treatment concepts, strategies and approaches to improve the therapeutic effect of bladder tumors.

[0003] Adenovirus is an ideal carrier for tumor gene therapy and biotherapy. Adenoviral vector has become a commonly used gene therapy vector because of its advantages of easy preparation of high titer virus, ability to infect dividing and non-dividing cel...

Claims

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