Microinjection device based on principle of friction

Abstract

The invention discloses a microinjection device based on the principle of friction. The microinjection device comprises an injector, a connecting piece and piezoelectric ceramics, wherein the injector is connected with the piezoelectric ceramics by use of the connecting piece; the connecting piece comprises a first fixing through hole and a second fixing through hole; the injector and the piezoelectric ceramics go through the first fixing through hole and the second fixing through hole, respectively, and are fixed in the connecting piece by use of frictional force; the injector comprises a clamping rod, a nylon tube and a microneedle; the piezoelectric ceramics comprise a piezoelectric ceramic crimping part, a piezoelectric ceramic main body part and a piezoelectric ceramic connecting column. The microinjection device based on the principle of friction has the advantages that the displacement of the stacked piezoelectric ceramics is transferred by use of the frictional force, the traditional threaded connection manner is abandoned and the mounting error and the threaded gap of the threaded connection are avoided, and therefore, low polarization and high positioning accuracy can be obtained without mercury, tiny polarization is obtained while guaranteeing that the microinjection device has relatively high positioning accuracy, and a relatively high success rate can be obtained during cell injection.

Description

technical field [0001] The invention relates to the technical field of microinjection, in particular to a microinjection device based on the principle of friction. Background technique [0002] Microinjector is an essential device for cell nucleus transplantation, microinjection and transgene injection in the field of biological sciences, and microinjection device is the key mechanism in the fiber injection process. Existing cell injection generally adopts mechanical transmission, hydraulic ball hinge and other driving methods for microinjection. In order to reduce the cell deformation caused by microinjection acupuncture membrane, the operator mostly uses the injection needle back suction method on the cell membrane. A through hole is drilled for the advance and retreat of the microinjection needle. This process is cumbersome to operate, has low production efficiency and is easy to damage cells. In the latest cell injection technology, electric micro-manipulators appear, ...

AI Technical Summary

Problems solved by technology

Although this kind of device can significantly improve the accuracy and operating efficiency, and reduce the damage of injection to the cell membrane, the microinjection device with this structure needs to add mercury to reduce the needle tip polarization caused by the installation error of the threaded connection. However, because mercury has Highly toxic, so the device poses a safety hazard to the operator

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