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Medicine for treating pregnancy with hyperthyroidism
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A thyroid function and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as affecting the normal development of the fetus, affecting postpartum lactation, and dysplasia of the placenta.
Inactive Publication Date: 2015-03-11
张丽
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At the same time, because the existing ATD can pass through the placental barrier, there are hidden dangers to the growth and development of the fetus. For example, excessive ATD will cause fetal hypothyroidism and goiter, which will affect the normal development of the fetus. Therefore, the existing clinical treatment plans mostly advocate pregnancy. The minimum dose of ATD should be applied in the long term, and the FT4 should not exceed 1.4 times the upper limit of normal
Due to the inability to use therapeutic drugs in sufficient quantities, FT4 remains at a high level, so the maternal and infant complications (such as miscarriage, premature delivery, fetal growth retardation, pregnancy-induced hypertension syndrome, etc.) of ATD treatment at this safe dose are not ideally controlled, and breastfeeding The recurrence rate in the early period is as high as 50% to 60%, which affects postpartum breastfeeding.
In addition, if the mother's hyperthyroidism has not been properly treated, neonatal hyperthyroidism will occur in 1 to 3% of the cases, and the mortality rate may reach 10% to 15%.
[0005] In addition, since β-adrenergic blockers can increase uterine muscle tone, resulting in placental dysplasia and fetal intrauterine growth retardation, it should not be used as the drug of choice in hyperthyroidism during pregnancy
For the control of tachycardia associated with PCH, there is currently no better drug
Method used
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Embodiment 1
[0030] Example 1, the weight ratio of raw materials: 20g of crabgrass, 20g of Pingdimu, 6g of Gengtongcao, 10g of onion, 10g of red clover, 6g of loofah, 10g of lotus leaf, 2g of bottlefern, 6g of hemp seed, and tianmulan 10g, pituitary bark 10g.
[0031] The preparation method of embodiment 1 is: mix crabgrass, flat ground wood, stalk grass, red clover, towel gourd, scallion, magnolia tianmulan, pituitary bark, lotus leaf, bottlefern, hemp seed, add water and decoct, 30 After 2 minutes, take the filtrate, add water to the dregs and continue to decoct for 20 minutes, then take the filtrate, combine the two filtrates, divide it into two parts and take it in the morning and evening.
Embodiment 2
[0032] Example 2, the weight ratio of raw materials: 10 parts of crabgrass, 10 parts of flat wood, 10 parts of stalk grass, 6 parts of red clover, 3 parts of loofah, 6 parts of shallot, 6 parts of magnolia, 6 parts of pituitary bark 6 parts of lotus leaf, 1 part of bottlefern, 3 parts of hemp seed, 10 parts of burnt grain buds, and 1 part of iron moth.
Embodiment 3
[0033] Example 3, the weight ratio of raw materials: 20 parts of crabgrass, 20 parts of flat ground wood, 6 parts of Gantongcao, 10 parts of red clover, 6 parts of loofah, 10 parts of shallot, 10 parts of magnolia, 10 parts of Pittosporum bark 10 parts of lotus leaf, 2 parts of bottle fern, 6 parts of hemp seed, 20 parts of burnt grain buds, and 3 parts of iron moth.
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technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a medicine for treating pregnancy complicated with hyperthyroidism. Background technique [0002] The incidence of pregnancy complicated hyperthyroidism (pregnancy complicating hyperthyroidism, PCH) is about 0.1% to 0.4%. Among the endocrine diseases in pregnant women, thyroiddisease ranks second only to diabetes. PCH is a high-risk disease of pregnancy, which is extremely harmful. The pregnancy loss rate is as high as 26%, and the premature delivery rate is 15%. It is also prone to fetal growth restriction (FGR), and its most important impact on the mother is thyroidstorm. Once it occurs, the mortality rate can be as high as 25%, so it is very important to give timely and appropriate treatment to PCH patients during pregnancy. [0003] The vast majority of PCH is Grave's disease, which accounts for more than 85% of all patients with hyperthyroidism. The exact mech...
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