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A kind of polymer and its preparation method and application

A technology of polymers and uses, applied in pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as needle blockage, affecting drug release, and drug administration loss.

Active Publication Date: 2018-08-17
张雅珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventors have invented a slow-controlled drug release material with special properties. The material is characterized in that it can pass through needles with a needle size of 30 and smaller and finer continuously without any interruption. During the test and clinical use of the drug prepared by releasing the material, it is easy to cause the needle to be blocked, which will cause a large amount of loss of the drug during the administration process, which will affect the release of the drug in the body, and indirectly affect the blood drug concentration and concentration of the drug. drug peak time

Method used

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  • A kind of polymer and its preparation method and application
  • A kind of polymer and its preparation method and application
  • A kind of polymer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A mixture of 1.5 g of sebacic acid in 50 ml of acetic anhydride was refluxed to form acetylated sebacic acid;

[0056] 2 Compound A 3g,

[0057]

[0058] Compound B 51mg,

[0059]

[0060] 165 mg of dicyclohexylcarbodiimide and 8 mg of pyridine were mixed, stirred overnight at room temperature; then washed with ether, and dried under vacuum to obtain a polymer;

[0061] 3 Mix the products of step 1) and step 2) into a flask, melt and polymerize under reduced pressure at 180°C for 1 hour; dissolve the polymer in chloroform after cooling to room temperature, wash with petroleum ether and dry;

[0062] get the structure as

[0063]

[0064] polymer

Embodiment 2

[0066] 1 The mixture of 2 g of sebacic acid in 20 ml of acetic anhydride is refluxed to form acetyl-sebacic acid;

[0067] 2 Compound A 2.5g,

[0068]

[0069] Compound B 42mg,

[0070]

[0071] 150 mg of dicyclohexylcarbodiimide and tetrahydrofuran were mixed and added with 15 ml of chloroform, stirred overnight at room temperature; then washed with ether and dried under vacuum to obtain a polymer;

[0072] 3 Mix the products of step 1 and step 2 into a flask, and react at 150°C for 1 hour; when the polymer is cooled to room temperature, dissolve it with chloroform, wash with petroleum ether and dry;

[0073] get the structure as

[0074]

[0075] of polymers.

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PUM

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Abstract

The invention discloses a new non-linear multi-block polymer and a preparation method and an application of the polymer. In comparison with polymers in other forms or medicines or medicaments of polymers, the non-linear multi-block polymer is extremely efficient and smooth when passing through a very fine syringe needle. The polymer provided by the invention is remarkably different from other polymers.

Description

technical field [0001] The invention discloses a new kind of non-linear multi-block polymer, as well as the preparation method and application of the polymer. Background technique [0002] At present, due to the diversification of drug delivery methods and the characteristics of the drug itself, many kinds of injections have put forward a lot of requirements for drug excipients and drug packaging materials. The present inventors have invented a drug slow-controlled release material with special properties. The material is characterized in that it can pass through needles with a needle size of 30 and smaller and finer continuously without any interruption. During the test and clinical use of the drug prepared by releasing the material, it is often easy to cause the needle to be blocked, resulting in a large amount of loss of the drug during the administration process, which in turn affects the release of the drug in the body, and indirectly affects the blood drug concentratio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/44A61K47/60A61K47/34
Inventor 张雅珍李铁力
Owner 张雅珍