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Traditional Chinese medicine effective part composition for treating trigeminal neuralgia and preparation method thereof

A technology for trigeminal neuralgia and effective parts, applied in the direction of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of lack of effective and side-effect-free therapy, achieve no toxic side effects, and the preparation method is simple and easy Good effect with high yield

Inactive Publication Date: 2015-03-25
张群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern Western medicine still lacks effective and side-effect-free treatments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 30g of Xu Changqing, 25g of Guazijin, 15g of Yibeimu, 15g of Tangerine, 10g of Wood Butterfly and 5g of Perilla, grind them into coarse powder, add 18 times the amount of water, and cook 3 times for 1 hour each time; filter After the decoction, combine the filtrates, concentrate under reduced pressure to a paste with a relative concentration of 1.15, add ethanol to make the alcohol content 68%, let it stand overnight, recover ethanol, and obtain 1000ml of concentrated solution, take simple syrup, add the above concentrated solution, And use citric acid to adjust the pH to 5, add distilled water to 5000ml, stir evenly, filter and pack into 15ml glass bottles, and pack to obtain oral liquid.

[0019] This product is a brown transparent liquid, which will not become turbid within half a year, with a pH of about 5 and a total solid of about 9%.

Embodiment 2

[0021] 500 cases of patients were observed clinically, and all patients had obvious clinical symptoms of trigeminal neuralgia and were diagnosed by clinicians.

[0022] Oral the oral liquid that embodiment 1 makes, every day 2 times, each 15ml. Medication time is 15 days.

[0023] After 15 days, the statistical results of patients using the oral liquid obtained in Example 1 are shown in Table 1.

[0024] Efficacy criteria: markedly effective means that after treatment, the pain is relieved, all symptoms disappear, and no recurrence is found in the follow-up for more than half a year; ineffective means that the pain degree and attack frequency are not significantly relieved or the symptoms are not improved after treatment.

[0025] Table 1

[0026] Number of cases markedly effective invalid Significant efficiency (%) 500 499 1 99.8

[0027] As can be seen from Table 1, the oral liquid obtained in Example 1 has special effects in the treatment of tr...

Embodiment 3

[0029] The oral liquid prepared in Example 1 was used to administer ICR mice with a body weight of 20-25 g, half male and half male, and the administration was continued for 90 days.

[0030] After pre-testing, the toxicity of the lotion prepared in Example 1 was very low, and the LD50 could not be measured, so the maximum daily dosage was determined for mice. The maximum dosage is 150ml / d. After 90 days, there is no case of poisoning death, and all of them are alive and healthy. This proves that the oral liquid made from the composition of the present invention will not cause toxic and side effects to the human body.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine effective part composition for treating trigeminal neuralgia and a preparation method thereof. The traditional Chinese medicine effective part composition is prepared by taking paniculate swallowwort root, Japanese milkwort herb, sinkiang fritillary bulb, tangerine pith, Indian trum etflower seed and white perilla seed as raw materials according to certain weight parts. The traditional Chinese medicine effective part composition disclosed by the invention can be prepared into a medicine for treating trigeminal neuralgia, has the effects of expelling wind and removing cold, warming the channels and relieving pain, and purging the liver fire and removing fire, can be used for significantly treating trigeminal neuralgia, and also has the advantages of no toxic or side effects and high safety.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine compositions, in particular to a composition of active parts of traditional Chinese medicines for treating trigeminal neuralgia and a preparation method thereof. Background technique [0002] Trigeminal neuralgia refers to recurrent paroxysmal short-term severe pain in the distribution area of ​​the trigeminal nerve. The clinical manifestations are mostly seen on one side of the face. Severe pain often occurs suddenly and lasts for several seconds within 1 to 2 minutes. In severe cases, facial twitching may occur. More onset after the age of 40. Modern western medicine still lacks effective and no side effect therapy. Contents of the invention [0003] The object of the present invention is to provide a Chinese medicine effective part composition for treating trigeminal neuralgia, which can quickly and effectively treat trigeminal neuralgia, has remarkable therapeutic effect, high s...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P25/02A61P29/00
CPCA61K9/0053A61K9/08A61K36/185A61K36/27A61K36/535A61K36/69A61K36/752A61K36/8966A61K2236/15A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 张群
Owner 张群
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