Mineralized collagen-base supporting apparatus for femur head

一种矿化胶原、支撑装置的技术,应用在骨植入物、运输和包装、内部骨合成等方向,能够解决来源有限、塌陷加重、免疫原性问题等问题,达到良好生物相容性、防止继续塌陷、优异机械性能的效果

Active Publication Date: 2015-03-25
杨述华 +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the actual production process, due to the limitation of the size of human bones, it is impossible to prepare allograft bone femoral head support devices with a length greater than 5cm, which greatly limits its clinical application
In addition, allogeneic bone also has limited sources, immunogenicity issues, and medical ethics issues.
[0006] To sum up, the existing treatment methods for femoral head collapse have their own defects, resulting in unsatisfactory treatment effects. Early femoral head necrosis often further develops into collapse, or the existing collapse is further aggravated, and finally hip replacement has to be performed surgery

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mineralized collagen-base supporting apparatus for femur head
  • Mineralized collagen-base supporting apparatus for femur head
  • Mineralized collagen-base supporting apparatus for femur head

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] In order to better illustrate the content of the present invention, the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0038] figure 1 Shown is the flow chart of the preparation process of the mineralized collagen-based femoral head support device described in the embodiment of the present invention. according to figure 1 As shown in the steps, the preparation process of the mineralized collagen-based femoral head support device is:

[0039] Step S1-1, dissolving 5 g of collagen in 10 L of acetic acid solution with a concentration of 0.5 mol / L to prepare an acid solution of collagen;

[0040] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 1L of CaCl with a concentration of 1mol / L dropwise 2 solution;

[0041] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 1 L of Na with a concentration of 0.6 mol / L dropwise 2 HPO 4 solution;

[004...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A femoral head support device, in particular a mineralized collagen-based femoral head support device applicable to the treatment of early osteonecrosis of femoral head. The device is made from a dense, homogeneous organic / inorganic composite, wherein the organic phase includes collagen and the inorganic phase includes nano calcium phosphate salt, and the device is of a cylinder having an upright through hole and also has a support strength of up to 4000-6000 N. By implementing a method for manufacturing such mineralized collagen-based femoral head support device, the mineralized collagen-based femoral head support device with mechanical properties equivalent to human cortical bone can be manufactured; and the mineralized collagen-based femoral head support device can meet the demand for the clinical treatment of early osteonecrosis of femoral head to avoid the continuous collapse of necrotic femoral head.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a femoral head support device, in particular to a mineralized collagen-based femoral head support device which can be used for treating early femoral head necrosis. technical background [0002] Necrosis of the femoral head is a common disease in orthopedics. There are currently many treatments to prevent the collapse of the femoral head. These treatments employ drilled holes and implanted supports to lift the collapsed femoral head from the inside out. Commonly used clinical supports include: metal support devices (such as memory titanium alloy mesh, tantalum rods, etc.), autologous cortical bone (such as autologous iliac crest), and allogeneic bone support devices. [0003] The memory titanium alloy mesh is difficult to control during the support process, which can easily lead to insufficient or excessive support; while metal supports such as tantalum rods are implanted into t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/42A61L27/58A61F2/28
CPCA61L27/46A61B17/58A61B17/68A61B17/72A61B17/74A61F2/2846A61F2/32A61L27/425A61L27/50A61L2430/02A61L2430/24B29C43/00B29C43/003B29C43/006B29C43/02B29C43/027B29L2031/7532Y10T428/1372C08L89/06
Inventor 杨述华王昶明仇志烨崔福斋刘先哲许伟华叶树楠王晶张义平李亚莉
Owner 杨述华
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products