Method for synthesizing p-chlorobenzaldehyde from p-chlorotoluene
A technology for p-chlorobenzaldehyde and p-chlorotoluene, which is applied in chemical instruments and methods, preparation of carbonyl compounds by hydrolysis, preparation of halogenated hydrocarbons, etc. cheap effect
Inactive Publication Date: 2015-03-25
CHANGSHU XINHUA CHEM
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
At present, the total domestic production is less than 1000t / a, which is far from meeting the domestic market demand of more than 2500t / a
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0018] React p-chlorotoluene with chlorine gas at 160°C for 8 hours in the presence of an initiator (1wt%) to generate p-chlorobenzyl chloride, and then catalyze (0.5wt% catalyst) hydrolysis for 12 hours to obtain p-chlorobenzaldehyde.
Embodiment 2
[0020] React p-chlorotoluene with chlorine gas at 180°C for 3 hours in the presence of an initiator (1.5wt%) to generate p-chlorobenzyl chloride, and then catalyze (0.8wt% catalyst) hydrolysis for 6 hours to obtain p-chlorobenzaldehyde.
Embodiment 3
[0022] React p-chlorotoluene with chlorine gas at 170°C for 6 hours in the presence of an initiator (1.2wt%) to generate p-chlorobenzyl chloride, and then catalyze (0.65wt% catalyst) hydrolysis for 8 hours to obtain p-chlorobenzaldehyde.
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The invention discloses a method for synthesizing p-chlorobenzaldehyde from p-chlorotoluene. The method comprises the steps of reacting the p-chlorotoluene with chlorine for 3-8 hours at 160-180 DEG C in the presence of an initiator to generate p-chlorobenzyl chloride, and then performing catalytic hydrolysis for 6-12 hour to obtain p-chlorobenzaldehyde. The method for synthesizing p-chlorobenzaldehyde from p-chlorotoluene is cheap in raw material and simple and convenient in operation.
Description
technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a method for synthesizing p-chlorobenzaldehyde from p-chlorotoluene. [0002] Background technique [0003] p-Chlorobenzaldehyde is an important intermediate of new pesticides, medicines and dyes. In medicine, p-chlorobenzaldehyde can be condensed and cyclized with mercaptopropionic acid to prepare fenalu. In terms of pesticides, p-chlorobenzaldehyde is used to synthesize the herbicide Maidi San, the plant growth regulator paclobutrazol and uniconazole, etc. In terms of dyes, p-chlorobenzaldehyde is used to synthesize acid blue 7BF, acid brilliant blue 6B, etc. [0004] The country that produces p-chlorobenzaldehyde abroad is mainly the United States, which is at the leading level in process technology development and has realized industrial production. Although the research and development of p-chlorobenzaldehyde started late in my country, it has developed rapidly...
Claims
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IPC IPC(8): C07C47/55C07C45/43C07C45/42
CPCC07C45/42C07C17/14C07C47/55C07C25/02
Inventor 窦建华陆志忠徐俊德
Owner CHANGSHU XINHUA CHEM