Degradable porous poly lactic acid preparation method

Abstract

The present invention discloses a degradable porous poly lactic acid preparation method, which comprises: adopting L-lactide as a raw material, adopting a stannous octoate catalyzed ring opening method to synthesize tri-arm poly lactic acid, preparing a macromolecule initiator, carrying out ring opening polymerization on the tri-arm poly lactic acid and benzyl glutamate carboxylic anhydride (NCA) to obtain a star block polymer adopting PLA as the core and adopting poly benzyl glutamate (PBLG) as the arm, carrying out hydrolysis to remove the benzyl protection group in the PBLG to obtain a star poly lactic acid/poly glutamic acid block copolymer, adding a low molecular weight poly glutamic acid, and dissolving with water by utilizing the amphiphilicity of the block copolymer to form the nano-scale porous material. According to the present invention, the block copolymer has a hexagonal columnar structure, the continuous phase is the poly lactic acid, and the material has the nano-scale hole and has the following advantages that: the material has the nano-scale micro-pores, the disadvantage that the traditional linear poly lactic acid material processability is poor is overcome, the material does not have the toxic-side effect, can be adopted as a drug carrier material, can be adopted as a medical implant material, and can be adopted as a part material of the in vivo sustained drug delivery device.

Description

technical field [0001] The invention relates to a degradable polylactic acid material, in particular to a preparation method of a block polymer material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, and the final metabolite is CO 2 and H 2 O, harmless to ...

AI Technical Summary

Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

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