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Eucommia lignanoid preparation for reducing blood pressure and preparation method of eucommia lignanoid preparation

A technique of Eucommia lignan and lignan, which is applied in the field of Eucommia lignan preparation and preparation thereof, can solve the problems of little improvement in activity, neglect, etc., and achieves the effects of simple extraction method, clear active ingredients, and improved antihypertensive activity.

Active Publication Date: 2015-04-01
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology only focuses on the total lignan content and yield in the extraction of eucommia lignans and ignores the optimization of the activity of eucommia lignan extracts, resulting in the eucommia lignans prepared by different methods The content and yield of the extract are constantly increasing, but the activity is not much improved, especially the antihypertensive activity

Method used

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  • Eucommia lignanoid preparation for reducing blood pressure and preparation method of eucommia lignanoid preparation
  • Eucommia lignanoid preparation for reducing blood pressure and preparation method of eucommia lignanoid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Get Eucommia bark 10kg and pulverize, sieve; Add the entraining agent (entraining agent is made up of ethanol and ammoniacal liquor, the volume percentage of the two is 85%:15%) that material-liquid weight ratio is 1:0.05 in the Eucommia bark that pulverizes, soak After 8 hours, stir evenly and add it to the extraction kettle. The pressure in the kettle is 10MPa. Using supercritical carbon dioxide fluid extraction technology, at a temperature of 30°C, static extraction for 0.5 hours, and then dynamic extraction at 2L / min for 0.5 hours; Eucommia lignan extract 723g.

[0018] The percentage by weight of the main active ingredients of the eucommia lignan extract detected by HPLC-MS is 15.7% of pinoresin diglucoside, 5.5% of syringaresin diglucoside, 3.5% of pinoresin A diglucoside, and olivine diglucoside Glycosides 8.8%, citrusin B 3.2%.

Embodiment 2

[0020] Get 10kg of eucommia bark and pulverize and sieve; add an entrainer with a weight ratio of material to liquid of 1:0.2 (entrainer is composed of ethanol and ammonia water, and the volume percentage of the two is 85%:15%) in the pulverized ulmoides bark, soak After 12 hours, stir evenly and add it to the extraction kettle. The pressure in the kettle is 20MPa. Using supercritical carbon dioxide fluid extraction technology, at a temperature of 50°C, static extraction for 1 hour, and then dynamic extraction at 10L / min for 2 hours; Eucommia lignan extract 857g.

[0021] The weight percent of the main active ingredients of the eucommia lignan extract detected by HPLC-MS is 10.2% of pinoresin diglucoside, 7.8% of syringaresin diglucoside, 5.6% of pinoresin A diglucoside, and olivine diglucoside Glycoside 7.4%, citrusin B 2.5%.

Embodiment 3

[0023] Get 10kg of eucommia bark and pulverize and sieve; add an entrainer with a weight ratio of material to liquid of 1:0.1 (the entrainer is made up of ethanol and ammonia water, and the volume percentage of the two is 85%:15%) in the pulverized ulmoides bark, soak After 10 hours, stir evenly and add it to the extraction kettle. The pressure in the kettle is 15MPa. Using supercritical carbon dioxide fluid extraction technology, at a temperature of 40°C, static extraction for 1 hour, and then dynamic extraction at 8L / min for 1 hour; Eucommia lignan extract 923g.

[0024] The weight percent of the main active ingredients of the eucommia lignan extract detected by HPLC-MS is 12.5% ​​pinoresin diglucoside, 10.7% syringaresin diglucoside, 7.3% pinoresin A diglucoside, olivine diglucoside Glycosides 10.2%, citrusin B 3.1%.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a eucommia lignanoid preparation and a preparation method of the eucommia lignanoid preparation. The eucommia lignanoid preparation comprises the following raw materials in percentage by weight: 5%-20% of pinoresinol diglucoside, 5%-15% of syringaresinol diglucoside, 1%-10% of pinoresinol A diglucoside, 5%-15% of olivil biglucoside, and 1%-5% of naringenin B, wherein a eucommia lignanoid extract preferably contains 10%-15% of pinoresinol diglucoside, 8%-12% of syringaresinol diglucoside, 5%-8% of pinoresinol A diglucoside, 8%-12% of olivil biglucoside and 2%-4% of naringenin B.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a eucommia lignan preparation and a preparation method thereof. Background technique [0002] Eucommia ulmoides (Eucommia ulmoides), also known as Sixian and silk cotton tree, is a unique single species plant in my country and a second-class national rare protected plant. It is mainly distributed in Gansu, Shaanxi, Henan, Hubei, Shanxi, Hunan, Sichuan, Yunnan, Guizhou, Guangxi, Fujian and other provinces. Its skin, stems, and leaves can be used as medicine, and its traditional pharmacological effects are "invigorating liver and kidney, strengthening muscles and bones, lowering blood pressure, etc." Modern studies have shown that Eucommia contains a variety of active ingredients, which have the effects of promoting body functions, anti-aging, and anti-cancer, especially the "two-way regulation" effect on high blood pressure. In my country, Eucommia is also...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/12
Inventor 肖军平吴永忠毛金娣杨伟庆周朝忠
Owner JIANGXI POZIN PHARMA
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