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Method for extracting O-methyl nandinine from Nandina domestica

A technology of methyl nantiana and nantiana, which is applied in the field of extracting O-methyl nantiana, can solve problems such as the operation method not specifically mentioned, and achieve the effects of high yield, easy operation, and less solvent

Active Publication Date: 2015-04-01
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zheng Junhua and others published "Alkaloids of Nandina chinensis", which used methanol extraction to obtain O-methyl nantianaine from the non-phenolic base part, but did not specifically mention the operation method. Separation and purification of alkaloids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 1 kg of nandina raw material and pulverize it, and extract with water (containing 10 g of formic acid) 3 times the mass of the raw material at 60°C with stirring, and extract twice in total to obtain the filtrate and filter residue.

[0026] The filter residue was then extracted with water (containing 30 g of hydrochloric acid) 5 times the mass of the raw material with stirring at 50° C. for a total of 2 extractions, and the extracts were combined.

[0027] Wet-pack 500mL of cationic resin 001×7 into the column, and absorb the above-mentioned extract on the column. After the adsorption is completed, use water (ammonia water containing 7% of the solution mass) to elute, TLC detection, and collect O-methyl The effluent of nantiana.

[0028] In addition, 500mL of anion resin 717 was wet-packed into the column, and the above-mentioned effluent containing O-methyl nantiandin was adsorbed on the column, and detected by TLC, and the effluent containing O-methyl nantiandin...

Embodiment 2

[0030] Take 1 kg of nandina raw material and pulverize it, and extract with water (containing 100 g of acetic acid) 6 times the mass of the raw material at 80°C with stirring and extraction for a total of 3 times to obtain filtrate and filter residue.

[0031] The filter residue was then stirred and extracted at 100°C with water (containing 20 g of sulfuric acid) 5 times the mass of the raw material, for a total of 2 extractions, and the extracts were combined.

[0032] 200mL of cationic resin D113 was wet-packed into the column, and the above-mentioned extract was adsorbed on the column. After the adsorption was completed, it was eluted with water (sodium hydroxide containing 2% of the solution mass), and detected by TLC. The effluent of nantiana.

[0033] In addition, 500mL of anion resin LSA700 was wet-packed into the column, and the above-mentioned effluent containing O-methyl nantianthine was adsorbed on the column, and detected by TLC, and the effluent containing O-methy...

Embodiment 3

[0035] Take 1 kg of nandina raw material and pulverize it, and extract with water (containing 40 g of acetic acid) twice the mass of the raw material at 50°C with stirring, and extract twice in total to obtain filtrate and filter residue;

[0036] The filter residue was then stirred and extracted at 80°C with water (containing 70 g of hydrochloric acid) 5 times the mass of the raw material, for a total of 2 extractions, and the extracts were combined.

[0037] Wet-pack 333mL cationic resin D113 into the column, put the above extract on the column for adsorption, after the adsorption is completed, use water (sodium carbonate containing 5% of the solution mass) to elute, TLC detection, and collect O-methyl Nantian Bamboo alkali effluent.

[0038] In addition, 200mL of anion resin LSA700 was wet-packed into the column, and the above-mentioned effluent containing O-methyl nantiandin was adsorbed on the column, and detected by TLC. The effluent containing O-methyl nantiandin spots ...

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Abstract

The invention provides a method for extracting O-methyl nandinine from Nandina domestica, which mainly solves the problems of complex operation, low product content, low recovery rate and inadaptability to mass production operation in the prior art. The method comprises the following steps: 1] primary extraction; 2] secondary extraction; 3] cationic resin adsorption purification; and 4] anionic resin adsorption decolorization. The method can be utilized to obtain the O-methyl nandinine product with the purity of greater than 98% only by several steps, and is convenient to operate. The method has the advantages of high product content, high recovery rate and small solvent hazard, and is suitable for mass production operation.

Description

technical field [0001] The invention belongs to the field of alkaloid extraction and separation, and relates to a method for extracting O-methyl nantiana, in particular to a method for extracting O-methyl nantiana from Nandina fruit. Background technique [0002] Nandina domestica, also known as Nandina domestica, belongs to the genus Nandina of the family Berberidaceae. It is a small evergreen ornamental shrub with ecological, ornamental, and medicinal values. Originally produced in China and Japan, it is mainly distributed in Shaanxi, Jiangsu, Zhejiang, Anhui and other places in my country. According to "Compendium of Materia Medica", "Compendium of Materia Medica Supplements" and other records, the fruit, root and leaves of nandina can be used as medicine, mainly treating conjunctivitis, cough, panting, food accumulation, diarrhea, hematuria, lumbar muscle strain, etc. Modern pharmacological studies have shown that it has the effects of lowering blood pressure, antibacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/06
CPCC07D491/06
Inventor 王晓莹肖红张瑜郭文华肖金霞
Owner SHAANXI JIAHE PHYTOCHEM
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