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Application of tgf-β1 receptor blocker in the preparation of drugs for preventing recurrence of echinococcosis

A receptor blocker and disease recurrence technology, applied in the field of biomedicine, can solve problems such as large damage to the human body, complex immune mechanism, and drug resistance

Inactive Publication Date: 2017-06-16
陈雪玲
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  • Description
  • Claims
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Problems solved by technology

However, this method has many disadvantages, such as large damage to the human body due to surgical treatment, and is prone to recurrence; chemotherapy with internal medicine such as mebendazole or albendazole can produce a lot of toxic and side effects, and some patients cannot tolerate it, or drug resistance
However, echinococcosis, like other parasitic diseases, is a chronic infection process, and its effect on the host is also a chronic and long-lasting process. The interaction between the two and the pathogenic immune mechanism are very complicated. The onset is insidious, and most patients come to the hospital for complications of echinococcosis

Method used

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  • Application of tgf-β1 receptor blocker in the preparation of drugs for preventing recurrence of echinococcosis
  • Application of tgf-β1 receptor blocker in the preparation of drugs for preventing recurrence of echinococcosis
  • Application of tgf-β1 receptor blocker in the preparation of drugs for preventing recurrence of echinococcosis

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Embodiment Construction

[0015] In order to illustrate the effect of the receptor blocking inhibitor of the present invention, the following experiment was carried out.

[0016] 1.1 Preparation of Echinococcus granulosus proscolm

[0017] From sheep livers infected with echinococcosis granulosus, aseptically extract the contents of uncalcified, non-infected, and whole cysts of echinococcosis granulosus into sterile centrifuge tubes, protoscole (Protoscole, PSC) ) to precipitate naturally, then rinse 2-3 times with sterile PBS (pH=7.3) containing 100IU / ml penicillin and streptomycin, remove the fragments of brood cysts to allow natural precipitation, stain with 0.5% eosin for 5min, and The number of active parasites (>90%) was identified under a microscope, diluted with sterile PBS containing double antibodies to prepare a protoscole suspension containing 10,000 protoscolmes / ml, and set aside.

[0018] 1.2 To establish a mouse model of Echinococcus granulosus infection, 16 healthy BALB / c mice were ran...

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Abstract

The invention discloses a use of a TGF-beta 1 receptor blocker in preparation of drugs for preventing echinococcosis recurrence. The applicant research shows that after use of the TGF-beta 1 receptor blocker in the mouse early suffering from echinococcosis granulosis cyst, a downstream molecule Smad2 / 3 phosphorylated protein expression level is reduced, NK cell active receptor NKG2D expression is improved, a target cell cracking rate of NK cells is recovered, NK cell activity is in a positive correlation relationship with active receptor NKG2D correlation analysis expression, a ratio of CD4<+> / CD8<+>T cell is high, and the amount of CD4<+>CD25<+>T cells. Therefore, the TGF-beta 1 receptor blocker can effectively prevent echinococcosis recurrence in clinical application.

Description

technical field [0001] The invention relates to a method for preventing the recurrence of echinococcosis, in particular to the application of a TGF-β1 receptor blocker in the preparation of medicines for preventing the recurrence of echinococcosis, belonging to the field of biomedicine. Background technique [0002] Echinococcosis, scientific name Ehcniocococsis (Ehcniocococsis), is a serious zoonotic parasitic disease caused by Echinococcus granulosus tapeworm larvae parasitizing in human body and some animals. Echinococcus tapeworms mainly include Echinococcus granulosus (E.g) and Echinococcus multilocularis (E.m). Cystic echinococcosis is a parasitic disease that seriously endangers human health caused by the larvae of Echinococcus granulosus parasitizing in human liver, lungs and other organs. It is widely distributed all over the world, so echinococcosis has become a global disease. issues affecting public health. [0003] Aiming at the treatment of echinococcosis, va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/517A61K31/4439A61K45/00A61P33/10
CPCA61K31/4439A61K31/498A61K45/00
Inventor 陈雪玲吴向未印双红
Owner 陈雪玲
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