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Composition for improving or promoting hair growth containing, as active ingredients, photosensitizer irradiated with light and peptide, and method using same

A sensitizer and peptide technology, applied in the field of hair growth improving or promoting compositions, can solve the problems of low hair growth effect, difficult, difficult to regenerate new hair follicles to play any role, etc., and achieves no cytotoxicity, low treatment effect of concentration

Inactive Publication Date: 2015-04-15
UNIQUEMEDICARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wigs, partial wigs, and hair enlargement can hide the bald part, but they cannot achieve hair growth effects. Although the two currently known drugs (minoxidil, finasteride) delay the further aggravation of hair loss, it is difficult to stimulate new hair follicles. regeneration of
In addition, many hair cosmetics use plant extracts to launch anti-hair loss products, especially the addition of sophora flavescens, capsicum, herb, mulberry bark, mulberry leaves, planting ginseng, licorice, peony, rehmannia, fennel, dogwood, garlic, etc. The product of extracts such as; the composition containing xanthine (xanthine) and growth hormone, improves the condition that is suppressed due to the excessive cell metabolism of dihydrotestosterone (DHT), and promotes the growth of hair through growth hormone, prevents hair loss and allows Hair regeneration, products showing hair growth effects; in order to promote hair growth, develop products containing minerals and vitamins, green tea, rosemary, mugwort, licorice extracts, supply nutrition to scalp and hair, and prevent hair loss And hair growth-promoting products that are effective in promoting hair growth, mix vitamin B, vitamin C, vitamin D, vitamin E, niacin, pantothenic acid, biotin and folic acid with plant extracts to inhibit 5-α reduction in the human body Enzyme, in the process of metabolism of androgen, prevents the formation of dihydrotestosterone and improves hair metabolism. Men's anti-hair loss products; but it is still difficult to find products that help the scalp to grow new hair
[0011] The hair growth or hair growth agents currently on the market have side effects such as hormones, or only produce effects on the activated parts of the hair roots. Although they are effective in preventing hair loss, they have very low hair growth effects on hair that has been in the resting period for a long time. Problems, or problems that will only be effective if you continue to eat or smear

Method used

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  • Composition for improving or promoting hair growth containing, as active ingredients, photosensitizer irradiated with light and peptide, and method using same
  • Composition for improving or promoting hair growth containing, as active ingredients, photosensitizer irradiated with light and peptide, and method using same
  • Composition for improving or promoting hair growth containing, as active ingredients, photosensitizer irradiated with light and peptide, and method using same

Examples

Experimental program
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Effect test

Embodiment

[0105] Experimental materials and experimental methods

[0106] Manufacture of natural extracts through hot water extraction

[0107] Add 10 times the amount of primary distilled water to 100 g of dried Cimicifuga heracleifolia, Baikl skullcap and Lance Asiabell, extract at 100°C for 6 hours, and then filter. The filtered extract was freeze-dried, powdered, and stored at 4°C until use. Powdered natural extract, used in rat experiments at a concentration of 1mg / ml.

[0108] Production of ALA (5-aminolevulinic acid: 5-aminolevulinic acid)-peptide (GHK)

[0109]Into a glass reactor for peptide synthesis (DeaGyang Science, KOR) equipped with a filter element (0.1 μm; Sigma, USA), 14.286 g of 2-Chlorotritylresin (MERCK, USA) was mixed (replaced rate, 1.40mmole / g; 20mmole), Fmoc-Lys(Boc)-OH 18.742g (40mmole / g; MERCK, USA), DIEA (N,N-diisopropylethylamine) 13.97ml (80mmole / g; MERCK, USA) , add MC (methylene chloride; MERCK, USA) 400ml, and react for more than 5 hours. 10 ml of m...

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Abstract

The present invention relates to a composition for improving or promoting hair growth, which contains, as an active ingredient, a photosensitizer / peptide conjugate, and to a method for screening for the hair growth promoter using the active ingredients. ALA, which is the photosensitizer of the present invention, is preferably activated by LED radiation, and more preferably activated by radiation having a long wavelength of 650 to 675 nm. The peptide of the present invention is a peptide in which 3 to 7 amino acid residues are incorporated (most preferably, glycine-histidine-lysine), and may cooperate with the photosensitizer to enable very superior hair growth improving or promoting effects using light radiation. Further, the composition of the present invention may exhibit further superior effects when natural extracts (for example, Cimicifuga heracleifolia extracts, Scutellaria baicalensis extracts or Codonopsis lanceolata extracts) are added. Thus, the composition of the present invention can be significantly advantageously applied to drugs, quasi-drugs, and cosmetics.

Description

technical field [0001] This patent application proposes a priority claim to Korean Patent Application No. 10-2012-0052403 submitted to the Korean Intellectual Property Office on May 17, 2012, and the disclosures of said patent application are cited in the description of the present invention as a reference. [0002] The present invention relates to a composition for improving or promoting hair growth containing a photosensitizer-peptide as an active ingredient and a method using the same using light. Background technique [0003] With the development of industry, the deepening of environmental pollution, the increase of life pressure, and the aging population, the incidence of alopecia or alopecia is gradually increasing. However, with the high development of human living standards, people pay more and more attention to the quality of life and their appearance. Alopecia in which a large amount of scalp hair falls out has many causes, such as (a) internal causes such as gene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K49/00A61P17/14A61P17/00
CPCA61K41/0061A61K8/41A61K8/64A61Q7/00A61K2800/57A61K2800/81A61K47/542A61K36/344A61K36/539A61K36/71A61K38/06A61P17/00A61P17/14A61P43/00A61K2300/00A61K47/50A61K49/00A61K47/64
Inventor D·威廉姆斯郑多云林淳镐
Owner UNIQUEMEDICARE
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