Application of 6-hydroxy-1-hydro-indazole in preparation of medicine for preventing and treating neurodegenerative disease

A neurodegenerative, hydroxyl-based technology that can be used in the medical field to solve problems such as uncontrollable disease progression and unstoppable neuron loss
CN104523682AInactive Publication Date: 2015-04-22ηŽ‹ζ–‡ι›…
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ηŽ‹ζ–‡ι›…
Publication Date
2015-04-22
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides an application of 6-hydroxy-1-hydro-indazole in preparation of medicine for preventing and treating neurodegenerative disease. An action mechanism of the medicine for preventing and treating neurodegenerative disease is characterized in that 6-hydroxy-1-hydro-indazole can inhibit a phosphorylation process of Tau protein, a hyperphosphorylation state of Tau can be alleviated, neuronal apoptosis can be prevented, so that a purpose for preventing and treating neurodegenerative disease can be reached. The application of 6-hydroxy-1-hydro-indazole in preparation of medicine for preventing and treating neurodegenerative disease can effectively inhibit the phosphorylation level of Tau protein and prevent neuronal apoptosis, the action target is clear, so that the therapeutic effect is definite and obvious.
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Description

technical field

[0001] The invention relates to the field of medical technology, in particular to the application of 6-hydroxy-1-hydro-indazole in the preparation of drugs for preventing and treating neurodegenerative diseases. Background technique

[0002] Neurodegenerative diseases refer to a series of diseases caused by the degenerative changes of neurons in the human body. They mainly occur in the elderly and greatly affect people's quality of life. Among them, Parkinson's disease (PD) and Alzheimer's disease (AD) are the two most common neurodegenerative diseases. Neuron loss due to neuron apoptosis is the main pathological feature of neurodegenerative diseases, but for a long time, due to the lack of clear drug targets, people can only use "palliative" methods to treat such diseases. Specific chemicals are taken or injected intravenously to replenish the depleted neurons in the patient's brain. For example, the signs and symptoms of PD can be relieved by drugs that i...

Claims

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